A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Saskia Houwing,Leonie M. Kamminga,Eugene Berezikov,Daniela Cronembold,Angélique Girard,Hans van den Elst,Dmitri V. Filippov,Heiko Blaser,Erez Raz,Cecilia B. Moens,Ronald H.A. Plasterk,Gregory J. Hannon,Bruce W. Draper,René F. Ketting +13 more
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TLDR
It is demonstrated that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component of a germline-specifying structure called nuage, implicating a role for piRNAs in the silencing of repetitive elements in vertebrates.About:
This article is published in Cell.The article was published on 2007-04-06 and is currently open access. It has received 1034 citations till now. The article focuses on the topics: Piwi-interacting RNA & RasiRNA.read more
Citations
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Biogenesis of small RNAs in animals.
TL;DR: This Review summarizes the current knowledge of how these intriguing molecules are generated in animal cells.
Journal ArticleDOI
Next-Generation DNA Sequencing Methods
TL;DR: An astounding potential exists for next-generation DNA sequencing technologies to bring enormous change in genetic and biological research and to enhance the authors' fundamental biological knowledge.
Journal ArticleDOI
Small silencing RNAs: an expanding universe
TL;DR: Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs.
Journal ArticleDOI
The impact of next-generation sequencing technology on genetics.
TL;DR: Next-generation sequencing technologies are surveyed and it is considered how they can provide a more complete picture of how the genome shapes the organism.
Journal ArticleDOI
Small non-coding RNAs in animal development
Giovanni Stefani,Frank J. Slack +1 more
TL;DR: Improved understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual miRNAs in mammals, and studies show that miRNA are key regulators of animal development and are potential human disease loci.
References
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