A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.
Angkana T. Huang,Bernardo García-Carreras,Matthew D. Hitchings,Bingyi Yang,Leah C. Katzelnick,Susan M Rattigan,Brooke A. Borgert,Carlos A. Moreno,Benjamin D. Solomon,Luke Trimmer-Smith,Veronique Etienne,Isabel Rodriguez-Barraquer,Justin Lessler,Henrik Salje,Henrik Salje,Henrik Salje,Donald S. Burke,Amy Wesolowski,Derek A. T. Cummings +18 more
TLDR
While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.Abstract:
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.read more
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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
Journal ArticleDOI
A serological assay to detect SARS-CoV-2 seroconversion in humans.
Fatima Amanat,Daniel Stadlbauer,Shirin Strohmeier,Shirin Strohmeier,Thi H. O. Nguyen,Veronika Chromikova,Meagan McMahon,Kaijun Jiang,Guha Asthagiri Arunkumar,Denise Jurczyszak,Jose Polanco,Maria Bermudez-Gonzalez,Giulio Kleiner,Teresa Aydillo,Lisa Miorin,Daniel S. Fierer,Luz Amarilis Lugo,Erna Milunka Kojic,Jonathan Stoever,Sean T. H. Liu,Charlotte Cunningham-Rundles,Philip L. Felgner,Thomas M. Moran,Adolfo García-Sastre,Daniel Caplivski,Allen C. Cheng,Katherine Kedzierska,Olli Vapalahti,Jussi Hepojoki,Jussi Hepojoki,Viviana Simon,Florian Krammer +31 more
TL;DR: A serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters and can be adjusted to detect different antibody types in serum and plasma.
Journal ArticleDOI
Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study.
Marina Pollán,Beatriz Pérez-Gómez,Roberto Pastor-Barriuso,Jesús Oteo,Miguel A. Hernán,Miguel A. Hernán,Mayte Pérez-Olmeda,Jose L Sanmartín,Aurora Fernández-García,Aurora Fernández-García,Israel Cruz,Nerea Fernández de Larrea,Marta Molina,Francisco Rodríguez-Cabrera,Mariano Martín,Paloma Merino-Amador,Jose León Paniagua,Juan F Muñoz-Montalvo,Faustino Blanco,Raquel Yotti,Rodrigo Gutiérrez Fernández,Saturnino Mezcua Navarro,Matías Salinero Hernández,Manuel Cuenca-Estrella,Pablo Fernández-Navarro,Ana Avellón,Giovanni Fedele,Jesús Oteo Iglesias,María Teresa Pérez Olmeda,Maria Elena Martinez,Francisco D. Rodríguez-Cabrera,Susana Padrones Fernández,José Manuel Rumbao Aguirre,José M. Navarro Marí,Begoña Palop Borrás,Ana Belén Pérez Jiménez,Manuel Rodríguez-Iglesias,Ana María Calvo Gascón,María Luz Lou Alcaine,Ignacio Donate Suárez,Oscar Suárez Álvarez,Mercedes Rodríguez Pérez,Margarita Cases Sanchís,Carlos Javier Villafáfila Gomila,Lluis Carbo Saladrigas,Adoración Hurtado Fernández,Antonio Oliver,Elías Castro Feliciano,María Noemí González Quintana,José María Barrasa Fernández,María Araceli Hernández Betancor,Melisa Hernández Febles,Leopoldo Martín Martín,Luis-Mariano López López,Teresa Ugarte Miota,Inés De Benito Población,María Sagrario Celada Pérez,María Natalia Vallés Fernández,Tomás Maté Enríquez,Miguel Villa Arranz,Marta Domínguez-Gil González,Isabel Fernández-Natal,Gregoria Megías Lobón,Juan Luis Muñoz Bellido,Pilar Ciruela,Ariadna Mas i Casals,Maria Doladé Botías,M. Angeles Marcos Maeso,Dúnia Pérez del Campo,Antonio Félix de Castro,Ramón Limón Ramírez,Maria Francisca Elías Retamosa,Manuela Rubio González,María Sinda Blanco Lobeiras,Alberto Fuentes Losada,Antonio Aguilera,Germán Bou,Yolanda Caro,Noemí Marauri,Luis Miguel Soria Blanco,Isabel González,Montserrat Hernández Pascual,Roberto Alonso Fernández,Natalia Cabrera Castro,Aurora Tomás Lizcano,Cristóbal Ramírez Almagro,M. Hernández,Nieves Ascunce Elizaga,María Ederra Sanz,Carmen Ezpeleta Baquedano,Ana Bustinduy Bascaran,Susana Iglesias Tamayo,Luis Elorduy Otazua,Rebeca Benarroch Benarroch,Jesús Lopera Flores,Antonia Vázquez de la Villa +95 more
TL;DR: In this paper, a nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level.
Journal ArticleDOI
Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.
Journal ArticleDOI
Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.
Yanjun Zhang,Gang Zeng,Hongxing Pan,Changgui Li,Yaling Hu,Kai Chu,Weixiao Han,Zhen Chen,Rong Tang,Weidong Yin,Xin Chen,Yuansheng Hu,Xiao-Yong Liu,Cong-Bing Jiang,Jingxin Li,Minnan Yang,Yan Song,Xiangxi Wang,Qiang Gao,Fengcai Zhu +19 more
TL;DR: The primary safety endpoint was adverse reactions within 28 days after injection in all participants who were given at least one dose of study drug (safety population).
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