Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Shorter periconception Maternal Telomere Length and the Risk of Congenital Cardiac Outflow Defects in the Offspring
TL;DR: Shorter maternal relative TL was associated with an approximately 1.3-OR for the risk, per SD in relative TL shortening, of ventricular septal defect (VSD) in the offspring as mentioned in this paper .
Journal Article
Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity
Shirley Hodgson,J Barwell,Laurent Pangon,Ian Kesterton,Anne Georgiou,R Gilchrist,Bernet S. Kato,Jacob D. Ball,Jonathan Berg,Zoe Docherty,Abraham Aviv,J. P. Gardner,Richard Camplejohn,Tim D. Spector +13 more
TL;DR: Mean terminal restriction fragment (TRF) lengths in white blood cells (WBCs) have been previously found to be associated with breast cancer susceptibility in women as discussed by the authors, however, this marker is not a marker of cancer susceptibility and does not vary significantly between affected women.
Journal ArticleDOI
Cardiometabolic profile and leukocyte telomere length in a Black South African population
Ndonwi E Ngwa,Tandi E. Matsha,Carl Lombard,Naomi S. Levitt,Eugene Sobngwi,Andre Pascal Kengne,Nasheeta Peer +6 more
TL;DR: In this paper , the authors investigated the association between leucocyte telomere length (LTL) and CMD risk profile in a black South African population, with a cross-sectional study with participants > 21 years of age and residing in five townships in Cape Town.
Journal ArticleDOI
An exploratory analysis of leukocyte telomere length among pregnant and non-pregnant people
Danielle M. Panelli,Mira Diwan,Giovanna Cruz,Stephanie A. Leonard,Jane Chueh,Ian H. Gotlib,Katherine Bianco +6 more
TL;DR: In this article , a pilot study compared changes in LTL between pregnant and non-pregnant people over time, explores potential correlations between LTL and mental health measures, and investigates associations between short first-trimester LTL, and adverse pregnancy outcomes.
Journal ArticleDOI
Potential antiaging and hepatoprotective effects of Acanthopanax senticosus extracts in adult rat models.
TL;DR: In this paper , the effects of Acanthopanax senticosus extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models were investigated.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.