Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
More filters
Journal ArticleDOI
Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
TL;DR: Positive associations between age and levels of oxidatively damaged DNA appeared mediated by age-related increases in metabolic risk factors.
Journal ArticleDOI
Effects of maternal exposure to ambient air pollution on newborn telomere length.
Lulu Song,Bin Zhang,Bingqing Liu,Mingyang Wu,Lina Zhang,Lulin Wang,Shunqing Xu,Zhongqiang Cao,Youjie Wang +8 more
TL;DR: It is suggested that maternal exposures to PM2.5, PM10, CO, and SO2 during the third trimester were related to shorter newborn TL, which highlights the importance of improving air quality in favor of subsequent health in later life of newborns.
Journal ArticleDOI
Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging.
Cathal McCrory,Giovanni Fiorito,Sinead McLoughlin,Silvia Polidoro,Cliona Ni Cheallaigh,Nollaig M. Bourke,Piia Karisola,Harri Alenius,Harri Alenius,Paolo Vineis,Richard Layte,Rose Anne Kenny +11 more
TL;DR: Results indicate that AL and the epigenetic clocks are measuring different age-related variance and implicate sex-specific drivers of biological ageing.
Journal ArticleDOI
Obesity, weight loss, and influence on telomere length: New insights for personalized nutrition
Caroline Rossi Welendorf,Carolina Ferreira Nicoletti,Marcela Augusta de Souza Pinhel,Natália Yumi Noronha,Bruna Morais Faleiros de Paula,Carla Barbosa Nonino +5 more
TL;DR: The relationship between obesity and TL is shown in addition to the possible risk factors for its shortening and how the different strategies for weight loss can modulate TL is considered, showing that TL may be used as a biomarker of responses to obesity treatment.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.