Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.
Journal ArticleDOI
Measuring biological aging in humans: A quest.
Luigi Ferrucci,Marta Gonzalez-Freire,Elisa Fabbri,Elisa Fabbri,Eleanor M. Simonsick,Toshiko Tanaka,Zenobia A. Moore,Shabnam Salimi,Felipe Sierra,Rafael de Cabo +9 more
TL;DR: Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging.
Journal ArticleDOI
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Jasminka Krištić,Frano Vučković,Cristina Menni,Lucija Klaric,Toma Keser,Ivona Bečeheli,Maja Pučić-Baković,Mislav Novokmet,Massimo Mangino,Kujtim Thaqi,Pavao Rudan,Natalija Novokmet,Jelena Šarac,Saša Missoni,Ivana Kolcic,Ozren Polasek,Igor Rudan,Harry Campbell,Caroline Hayward,Yurii S. Aulchenko,Ana M. Valdes,James F. Wilson,Olga Gornik,Dragan Primorac,Vlatka Zoldoš,Tim D. Spector,Gordan Lauc +26 more
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Journal ArticleDOI
Immunoglobulin G glycosylation in aging and diseases.
TL;DR: The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations, making it an excellent biomarker of a person's general health state and a promising add-on to improve existing disease biomarkers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
References
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Journal ArticleDOI
Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans
Ji Yeon Shin,Yi Young Choi,Hyo Sung Jeon,Jun Hyun Hwang,Sung Ae Kim,Jung Ho Kang,Yoon-Seok Chang,David R. Jacobs,Jae Yong Park,Duk Hee Lee +9 more
TL;DR: It is found that telomere length was increasing across low doses of exposure to POPs in which the majority of study subjects were found, suggesting that low-dose POPs may act as a tumour promoter in carcinogenesis in humans.
Journal ArticleDOI
Shared environmental factors associated with telomere length maintenance in elderly male twins.
TL;DR: The results emphasize that shared environmental factors can have a primary impact on telomere length maintenance in elderly humans and find that individuals with hypertension and cardiovascular disease had significantly shorter telomeres.
Journal ArticleDOI
Study of telomere length and different markers of oxidative stress in patients with Parkinson’s disease
Ghassan Watfa,C. Dragonas,Thorolf Brosche,R. Dittrich,Cornel C. Sieber,Cosmin Alecu,Athanase Benetos,Rosine Nzietchueng +7 more
TL;DR: In PD, TL is shorter in presence of high oxidative stress as measured by carbonyl protein levels, suggesting the absence of telomere attrition with age among patients with PD could reflect a telomeres regulation by mechanisms other than age.
Journal ArticleDOI
Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study.
Ramachandran S. Vasan,Serkalem Demissie,Masayuki Kimura,L. Adrienne Cupples,Charles L. White,Jeffrey P. Gardner,Xiaogian Cao,Daniel Levy,Emelia J. Benjamin,Abraham Aviv +9 more
TL;DR: In the present community-based sample, LTL was positively associated with LV mass and wall thickness, especially so in participants with hypertension, consistent with the hypothesis that longer LTL may be a marker of propensity to LV hypertrophy.
Journal ArticleDOI
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
Guangju Zhai,Abraham Aviv,David J. Hunter,Deborah J. Hart,Jeffrey P. Gardner,Masayuki Kimura,Xiaobin Lu,Ana M. Valdes,Tim D. Spector +8 more
TL;DR: Shorter leucocyte telomere length (LTL) equivalent to around 11 years of annual loss in normal people is associated with radiographic hand osteoarthritis and disease severity, suggesting potential shared mechanisms between osteoartritis and ageing, and implicating oxidative stress and low-level chronic inflammation in both conditions.