Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Racial Discrimination and Telomere Shortening Among African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
David H. Chae,Yijie Wang,Connor D. Martz,Natalie Slopen,Tiffany Yip,Nancy E. Adler,Thomas E. Fuller-Rowell,Jue Lin,Karen A. Matthews,Gene H. Brody,Erica C Spears,Eli Puterman,Elissa S. Epel +12 more
TL;DR: Evidence is added that racial discrimination contributes to accelerated physiologic weathering and health declines among African Americans through its impact on biological systems, including via its effects on telomere attrition.
Journal ArticleDOI
Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease.
TL;DR: The current state of research paves the way for future work focused on identifying the peripheral and central biological mechanisms linking traumatic stress to accelerated biological aging and medical morbidity, with an emphasis on processes involved in inflammation, immune functioning, oxidative stress, autonomic arousal, and stress response.
Journal ArticleDOI
Defining the toxicology of aging.
TL;DR: This review discusses the evidence for the existence of mammalian gerontogens, as well as the biomarkers needed to measure the age-promoting activity of a given toxicant, and focuses on the effects of putative gerontogen on the in vivo accumulation of senescent cells.
Journal ArticleDOI
Is chronic asthma associated with shorter leukocyte telomere length at midlife
Daniel W. Belsky,Idan Shalev,Malcolm R. Sears,Robert J. Hancox,Hona Lee Harrington,Renate Houts,Terrie E. Moffitt,Karen Sugden,Benjamin Williams,Richie Poulton,Avshalom Caspi +10 more
TL;DR: Life-course-persistent asthma is related to a proposed biomarker of accelerated aging, possibly via systemic eosinophilic inflammation, according to a tested associations between asthma and leukocyte telomere length.
Journal ArticleDOI
Leukocyte telomere length in patients with bipolar disorder: An updated meta-analysis and subgroup analysis by mood status
TL;DR: The hypothesis of accelerated aging in BD patients is supported and further properly controlled longitudinal studies are warranted to determine whether LTL changes with disease status or medication use in patients with bipolar disorder.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.