Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD
Erica P.A. Rutten,Poornima Gopal,Emiel F.M. Wouters,Frits M.E. Franssen,Geja J. Hageman,Lowie E.G.W. Vanfleteren,Martijn A. Spruit,Niki L. Reynaert +7 more
TL;DR: Markers of the aging mechanism represent distinct molecular aspects of aging and only telomere length was consistently associated with lung function, and seems a useful marker for expressing accelerated aging in COPD.
Journal ArticleDOI
Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies.
Mohammad Miri,Milad Nazarzadeh,Ahmad Alahabadi,Mohammad Hassan Ehrampoush,Abolfazl Rad,Mohammad Hassan Lotfi,Mohammad Hassan Sheikhha,Mohammad Javad Zare Sakhvidi,Tim S. Nawrot,Payam Dadvand +9 more
TL;DR: A systematic review and conduct meta-analysis of published studies on the relationship between air pollution and telomere length (TL) in adults is presented in this article. But, there is no available systematic review of literature on this association.
Journal ArticleDOI
Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
Oliver Robinson,Marc Chadeau Hyam,Ibrahim Karaman,Rui Pinto,Mika Ala-Korpela,Mika Ala-Korpela,Evangelos Handakas,Giovanni Fiorito,Giovanni Fiorito,He Gao,Andy Heard,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Matthew M. Lewis,Raha Pazoki,Raha Pazoki,Silvia Polidoro,Ioanna Tzoulaki,Matthias Wielscher,Paul Elliott,Paolo Vineis +21 more
TL;DR: In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Journal ArticleDOI
Associations of Cadmium and Lead Exposure With Leukocyte Telomere Length: Findings From National Health and Nutrition Examination Survey, 1999–2002
Ami R. Zota,Belinda L. Needham,Elizabeth H. Blackburn,Jue Lin,Sung Kyun Park,David H. Rehkopf,Elissa S. Epel +6 more
TL;DR: Associations of blood lead and cadmium levels with leukocyte telomere length among a nationally representative sample of US adults from the National Health and Nutrition Examination Survey (1999-2002) are examined to provide further evidence of physiological impacts of Cadmium at environmental levels and might provide insight into biological pathways underlying cadMium toxicity and chronic disease risks.
Journal ArticleDOI
Longitudinal Associations Between Metabolic Syndrome Components and Telomere Shortening
TL;DR: Metabolic dysregulations are associated with shorter telomeres over two time points, and increasing abdominal adiposity is accompanied by accelerated telomere attrition.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.