Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.
Journal ArticleDOI
Measuring biological aging in humans: A quest.
Luigi Ferrucci,Marta Gonzalez-Freire,Elisa Fabbri,Elisa Fabbri,Eleanor M. Simonsick,Toshiko Tanaka,Zenobia A. Moore,Shabnam Salimi,Felipe Sierra,Rafael de Cabo +9 more
TL;DR: Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging.
Journal ArticleDOI
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Jasminka Krištić,Frano Vučković,Cristina Menni,Lucija Klaric,Toma Keser,Ivona Bečeheli,Maja Pučić-Baković,Mislav Novokmet,Massimo Mangino,Kujtim Thaqi,Pavao Rudan,Natalija Novokmet,Jelena Šarac,Saša Missoni,Ivana Kolcic,Ozren Polasek,Igor Rudan,Harry Campbell,Caroline Hayward,Yurii S. Aulchenko,Ana M. Valdes,James F. Wilson,Olga Gornik,Dragan Primorac,Vlatka Zoldoš,Tim D. Spector,Gordan Lauc +26 more
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Journal ArticleDOI
Immunoglobulin G glycosylation in aging and diseases.
TL;DR: The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations, making it an excellent biomarker of a person's general health state and a promising add-on to improve existing disease biomarkers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
References
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Journal ArticleDOI
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
Wei Chen,Jeffrey P. Gardner,Masayuki Kimura,Michael Brimacombe,Xiaojian Cao,Sathanur R. Srinivasan,Gerald S. Berenson,Abraham Aviv +7 more
TL;DR: As HDL-C exerts anti-oxidant and anti-inflammatory effects and LTL registers the accruing burden of oxidative stress and inflammation, the association between HDL- C and L TL might be explained by the lifelong status of oxidative Stress and inflammation.
Journal ArticleDOI
Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders.
Nobuya Obana,Sho Takagi,Yoshitaka Kinouchi,Yoshihisa Tokita,Akihiro Sekikawa,Seiichi Takahashi,Nobuo Hiwatashi,Shinichi Oikawa,Tooru Shimosegawa +8 more
TL;DR: Compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia and diabetes mellitus, according to the presence or absence of coronary diseases, demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomeres length than healthy controls.
Journal ArticleDOI
Telomere shortening in sleep apnea syndrome.
Antonia Barceló,Javier Piérola,Herminio López-Escribano,Mónica de la Peña,Joan B. Soriano,Alberto Alonso-Fernández,Antonio Ladaria,Alvar Agusti +7 more
TL;DR: TL in circulating leukocytes is shorter in patients with OSAS than subjects without OSAS, and the mechanism of this observation is unresolved since it appears independent of chronological age, the severity of OSAS and/or the presence of cardiovascular or metabolic alterations.
Journal ArticleDOI
Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking.
Tim S. Nawrot,Jan A. Staessen,Paul Holvoet,Harry A.J. Struijker-Boudier,Paul M. H. Schiffers,Luc M. Van Bortel,Robert Fagard,Jeffrey P. Gardner,Masayuki Kimura,Abraham Aviv +9 more
TL;DR: Higher level of oxidized-LDL, is associated with shorter WBC telomeres and increased stiffness of the carotid artery, and smoking is marked by increased oxidative stress in concert with shortened W BC telomere length.
Journal ArticleDOI
Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.
Michelangela Barbieri,Giuseppe Paolisso,Masayuki Kimura,Jeffrey P. Gardner,Virginia Boccardi,Michela Papa,Jacob v. B. Hjelmborg,Kaare Christensen,Michael Brimacombe,Tim S. Nawrot,Jan A. Staessen,Jan A. Staessen,Michael Pollak,Abraham Aviv +13 more
TL;DR: The findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans, and it will be necessary to establish whether LTL will ultimately be used in clinical settings as an index ofhealthy aging.