Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
More filters
Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.
Journal ArticleDOI
Measuring biological aging in humans: A quest.
Luigi Ferrucci,Marta Gonzalez-Freire,Elisa Fabbri,Elisa Fabbri,Eleanor M. Simonsick,Toshiko Tanaka,Zenobia A. Moore,Shabnam Salimi,Felipe Sierra,Rafael de Cabo +9 more
TL;DR: Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging.
Journal ArticleDOI
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Jasminka Krištić,Frano Vučković,Cristina Menni,Lucija Klaric,Toma Keser,Ivona Bečeheli,Maja Pučić-Baković,Mislav Novokmet,Massimo Mangino,Kujtim Thaqi,Pavao Rudan,Natalija Novokmet,Jelena Šarac,Saša Missoni,Ivana Kolcic,Ozren Polasek,Igor Rudan,Harry Campbell,Caroline Hayward,Yurii S. Aulchenko,Ana M. Valdes,James F. Wilson,Olga Gornik,Dragan Primorac,Vlatka Zoldoš,Tim D. Spector,Gordan Lauc +26 more
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Journal ArticleDOI
Immunoglobulin G glycosylation in aging and diseases.
TL;DR: The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations, making it an excellent biomarker of a person's general health state and a promising add-on to improve existing disease biomarkers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
References
More filters
Journal ArticleDOI
Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.
TL;DR: Reduced telomere length may be a marker of biological aging and may relate to increased risk for dementia and mortality, and it is hypothesized that telomeres length might thus relate toincreased risk for schizophrenia and mortality.
Journal ArticleDOI
Paternal age at birth is an important determinant of offspring telomere length
Tim De Meyer,Ernst Rietzschel,Marc De Buyzere,Dirk De Bacquer,Wim Van Criekinge,Guy De Backer,Thierry C. Gillebert,Patrick Van Oostveldt,Sofie Bekaert +8 more
TL;DR: Paternal age at birth is an important determinant for TL, with substantial consequences for future studies, as paternal age is subject to demographic evolution, its association with TL might have a substantial impact on the results and comparability of TL within and between epidemiological studies.
Journal ArticleDOI
Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study.
TL;DR: The current investigation has shown an association of mean leukocyte telomere length shortening with T2DM in white subjects, suggesting the potential importance of telomeres biology in type 2 diabetes mellitus.
Journal ArticleDOI
Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
Jennifer A. Nettleton,Ana V. Diez-Roux,Nancy S. Jenny,Annette L. Fitzpatrick,David R. Jacobs +4 more
TL;DR: Processed meat intake showed an expected inverse association with telomere length, but other diet features did not show their expected associations.
Journal ArticleDOI
Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets
TL;DR: If these associations are replicated in larger studies, they provide modest epidemiologic evidence that shortened telomere length may be associated with breast cancer risk.