Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.
Journal ArticleDOI
Measuring biological aging in humans: A quest.
Luigi Ferrucci,Marta Gonzalez-Freire,Elisa Fabbri,Elisa Fabbri,Eleanor M. Simonsick,Toshiko Tanaka,Zenobia A. Moore,Shabnam Salimi,Felipe Sierra,Rafael de Cabo +9 more
TL;DR: Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging.
Journal ArticleDOI
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Jasminka Krištić,Frano Vučković,Cristina Menni,Lucija Klaric,Toma Keser,Ivona Bečeheli,Maja Pučić-Baković,Mislav Novokmet,Massimo Mangino,Kujtim Thaqi,Pavao Rudan,Natalija Novokmet,Jelena Šarac,Saša Missoni,Ivana Kolcic,Ozren Polasek,Igor Rudan,Harry Campbell,Caroline Hayward,Yurii S. Aulchenko,Ana M. Valdes,James F. Wilson,Olga Gornik,Dragan Primorac,Vlatka Zoldoš,Tim D. Spector,Gordan Lauc +26 more
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Journal ArticleDOI
Immunoglobulin G glycosylation in aging and diseases.
TL;DR: The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations, making it an excellent biomarker of a person's general health state and a promising add-on to improve existing disease biomarkers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
References
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Journal ArticleDOI
Antioxidant properties of steroids
TL;DR: It is concluded that estrogens especially estriol and 17 beta-estradiol are naturally occurring antioxidants.
Journal ArticleDOI
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.
Carmen Martin-Ruiz,Jacobijn Gussekloo,Diana van Heemst,Thomas von Zglinicki,Rudi G. J. Westendorp +4 more
TL;DR: It is concluded that blood monocyte telomere length is not a predictive indicator for age‐related morbidity and mortality at ages over 85 years, possibly because of a high degree of telomeres length instability in this group.
Journal ArticleDOI
Common variants near TERC are associated with mean telomere length.
Veryan Codd,Veryan Codd,Massimo Mangino,Pim van der Harst,Peter S. Braund,Peter S. Braund,Michael A. Kaiser,Michael A. Kaiser,Alan J. Beveridge,Alan J. Beveridge,Suzanne Rafelt,Suzanne Rafelt,Jasbir S. Moore,Jasbir S. Moore,Christopher P. Nelson,Christopher P. Nelson,Nicole Soranzo,Guangju Zhai,Ana M. Valdes,Hannah Blackburn,Irene Mateo Leach,Irene Mateo Leach,Irene Mateo Leach,Rudolf A. de Boer,Rudolf A. de Boer,Rudolf A. de Boer,Alison H. Goodall,Alison H. Goodall,Willem H. Ouwehand,Dirk J. van Veldhuisen,Dirk J. van Veldhuisen,Dirk J. van Veldhuisen,Wiek H. van Gilst,Wiek H. van Gilst,Wiek H. van Gilst,Gerjan Navis,Gerjan Navis,Gerjan Navis,Paul Burton,Martin D. Tobin,Alistair S. Hall,John R. Thompson,Tim D. Spector,Nilesh J. Samani +43 more
TL;DR: In this article, the authors conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals.
Journal ArticleDOI
Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?
Gabriele Saretzki,von, Zglinicki, T,Serra,Mario Lorenz,R Lenzen-Grossimlighaus,R Gessner,Angela Risch,E Steinhagen-Thiessen +7 more
TL;DR: Leukocyte telomeres in patients with probable or possible vascular dementia were significantly shorter than in three age-matched control groups, namely in cognitively competent patients suffering from cerebrovascular or cardiovascular disease alone, in Patients with probable Alzheimer's dementia, and in apparently healthy control subjects.
Journal ArticleDOI
Telomere length measurement-caveats and a critical assessment of the available technologies and tools.
TL;DR: The goal of this review is to provide a comprehensive summary of the most commonly used methods for telomere length measurement and discuss the advantages and disadvantages of each.