Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time.
Anthony Y.Y. Hsieh,Elana Kimmel,Neora Pick,Laura Sauve,Jason Brophy,Fatima Kakkar,Ari Bitnun,Melanie C.M. Murray,Hélène C. F. Côté +8 more
TL;DR: A novel relationship between two established aging markers, whereby rates of change in LTL and WB mtDNA are inversely related is described, highlighting the importance of maintaining HIV viral control, the complementary longitudinal relationship between the two markers, and the need to consider both in aging studies.
Journal ArticleDOI
The impact of neighborhood context on telomere length: A systematic review.
Bruno Messina Coimbra,Carolina Muniz Carvalho,Mirjam van Zuiden,Rachel E. Williamson,Vanessa Kiyomi Ota,Andrea Feijo Mello,Sintia Iole Belangero,Miranda Olff,Marcelo Feijó de Mello +8 more
TL;DR: In this paper , the authors conducted a systematic review of studies that investigated the association between neighborhood context and telomere length (TL), a DNA-protein complex that shortens after cell division.
Journal ArticleDOI
Telomere length: biological marker of cellular vitality, aging, and health-disease process
TL;DR: The aging process occurs due to the decline of vital physiological functions and adaptability of the body, being influenced by genetics and lifestyle as mentioned in this paper, and biological aging can be calculated by telomere length.
Journal ArticleDOI
New asthma biomarkers: Shorter telomeres, longer disease?
TL;DR: Methods for quantification of local emphysema and airway disease patterns are also evolving, which will provide more opportunities to integrate these phenotypes with genetics and genomics for systems biology analyses and determination of molecular phenotypes in COPD.
Journal ArticleDOI
Association between internet gaming addiction and leukocyte telomere length in Korean male adolescents.
TL;DR: Results indicate that in addition to age, involvement in excessive Internet gaming may induce LTL shortening in male adolescents, which may be partially attributable to changes in autonomic function such as catecholamine level.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.