Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.
Journal ArticleDOI
Measuring biological aging in humans: A quest.
Luigi Ferrucci,Marta Gonzalez-Freire,Elisa Fabbri,Elisa Fabbri,Eleanor M. Simonsick,Toshiko Tanaka,Zenobia A. Moore,Shabnam Salimi,Felipe Sierra,Rafael de Cabo +9 more
TL;DR: Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging.
Journal ArticleDOI
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Jasminka Krištić,Frano Vučković,Cristina Menni,Lucija Klaric,Toma Keser,Ivona Bečeheli,Maja Pučić-Baković,Mislav Novokmet,Massimo Mangino,Kujtim Thaqi,Pavao Rudan,Natalija Novokmet,Jelena Šarac,Saša Missoni,Ivana Kolcic,Ozren Polasek,Igor Rudan,Harry Campbell,Caroline Hayward,Yurii S. Aulchenko,Ana M. Valdes,James F. Wilson,Olga Gornik,Dragan Primorac,Vlatka Zoldoš,Tim D. Spector,Gordan Lauc +26 more
TL;DR: This study has revealed very extensive and complex changes in IgG glycosylation with age, and the combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths.
Journal ArticleDOI
Immunoglobulin G glycosylation in aging and diseases.
TL;DR: The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations, making it an excellent biomarker of a person's general health state and a promising add-on to improve existing disease biomarkers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
References
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Journal ArticleDOI
Estimating age of humans based on telomere shortening
TL;DR: The terminal restriction fragment (TRF) length is determined, as telomere length, using Southern blot analysis of peripheral human blood and blood stains to give a rough estimation of age of subjects in forensic samples that carry no morphological information.
Journal ArticleDOI
Longer Relative Telomere Length in Blood from Women with Sporadic and Familial Breast Cancer Compared with Healthy Controls
TL;DR: This analysis supports previous findings of longer RTL in breast cancer cases compared with controls, and is the first to observe longer telomere length in women without breast cancer identified as high risk based on family history.
Journal ArticleDOI
Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes.
TL;DR: Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes and the FinnDiane Study Group is studied.
Journal ArticleDOI
Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
S. W. Brouilette,Andrew Whittaker,Suzanne Stevens,van der Pim Harst,Alison H. Goodall,Nilesh J. Samani +5 more
TL;DR: In this article, the authors investigated whether shorter telomeres are a primary abnormality or secondary to coronary artery disease in healthy young adults with contrasting familial risk of CAD and found a decrease in mean telomere restriction fragment (TRF) length in DNA from circulating leucocytes.
Journal ArticleDOI
No association between socio‐economic status and white blood cell telomere length
Jean Adams,Carmen Martin-Ruiz,Mark S. Pearce,Martin White,Louise Parker,Thomas von Zglinicki +5 more
TL;DR: The results of this and the previous study suggest that there is little evidence of a strong or consistent correlation between white blood cell telomere length and markers of socio‐economic status.