Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
Ivan Dimauro,Antonella Sgura,Monica Pittaluga,Fiorenza Magi,Cristina Fantini,Rosa Mancinelli,Antonio Sgadari,Stefania Fulle,Daniela Caporossi +8 more
TL;DR: The gene expression analysis in T2D subjects suggested an adaptive response to prolonged exercise training that improved the response of specific genes, including telomere length, spontaneous and H2O2-induced DNA damage, and apoptosis level in leukocytes.
Journal ArticleDOI
Epidemiological and Mendelian Randomization Studies of Dihydrotestosterone and Estradiol and Leukocyte Telomere Length in Men
Bu B. Yeap,Matthew Knuiman,Mark L. Divitini,Jennie Hui,Gillian M. Arscott,David J. Handelsman,Susan V. McLennan,Stephen M. Twigg,Brendan McQuillan,Joseph Hung,John Beilby +10 more
TL;DR: In men, serum DHT and E2 correlate with LTL independently of age, thus warranting further studies to examine whether hormonal interventions might slow biological aging in men.
Journal ArticleDOI
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation
Irene Pusceddu,Markus Herrmann,Susanne H. Kirsch,Christian Werner,Ulrich Hübner,Marion Bodis,Ulrich Laufs,Stefan Wagenpfeil,Jürgen Geisel,Wolfgang Herrmann +9 more
TL;DR: The results suggest a possible effect of B vitamins for telomere biology in blood cells and suboptimal B vitamins status and hyperhomocysteinemia are associated with altered DNA methylation and telomeres length.
Journal ArticleDOI
Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome.
Anna Aulinas,María José Ramirez,María-José Barahona,Elena Valassi,Eugenia Resmini,Eugenia Mato,Alicia Santos,Iris Crespo,Olga Bell,Jordi Surrallés,Susan M. Webb +10 more
TL;DR: Telomere length (TL) is shortened in dyslipidemic CS patients, further worse if hypertension and/or obesity coexist and is negatively correlated with increased inflammation markers.
Journal ArticleDOI
Super DNAging - New insights into DNA integrity, genome stability and telomeres in the oldest old
TL;DR: The most conclusive picture that emerges from reviewing the literature is that reaching "super old" age appears to be primarily determined by hereditary/genetic factors, while a healthy lifestyle additionally contributes to achieving the individual maximum lifespan in humans.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.