Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
In vivo biomarkers of structural and functional brain development and aging in humans.
Katja Franke,P. Bublak,Dirk Hoyer,Thibo Billiet,Christian Gaser,Otto W. Witte,Matthias Schwab +6 more
TL;DR: This work reviews current advances of in vivo biomarkers predicting individual brain age and concludes thatotype-related biomarkers of global cognitive function and brain structure provide a much closer correlation to age at the individual level.
Journal ArticleDOI
Exposure–Response Associations of Household Air Pollution and Buccal Cell Telomere Length in Women Using Biomass Stoves
Sabrina Li,Ming Yang,Ellison Carter,Ellison Carter,James J. Schauer,Xudong Yang,Majid Ezzati,Majid Ezzati,Mark S. Goldberg,Mark S. Goldberg,Jill Baumgartner,Jill Baumgartner +11 more
TL;DR: Telomere shortening, which is a biomarker of biological aging and chronic disease, may be associated with exposure to air pollution in settings where household biomass stoves are commonly used.
Journal ArticleDOI
Metal‐Ion‐Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells
TL;DR: This work provides a new way to modulate telomerase activity in living cells by using DNAzymes that can regulate cell behavior, including cell migration, cell differentiation, cell senescence, and cell cycle.
Journal ArticleDOI
Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan
Danielle Hiam,Cassandra Smith,Cassandra Smith,Sarah Voisin,Josh Denham,Xu Yan,Shanie Landen,Macsue Jacques,Javier Alvarez-Romero,Andrew Garnham,Mary N. Woessner,Markus Herrmann,Gustavo Duque,Itamar Levinger,Itamar Levinger,Nir Eynon +15 more
TL;DR: In healthy individuals, age explain most of the variability of LTL and this appears to be independent of individual aerobic capacity, but individuals with longer LTL also have a longer MTL, suggesting that there might be a shared molecular mechanism regulating telomere length.
Journal ArticleDOI
Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals.
TL;DR: Telomere length is associated with psychological burden though the direction of effect differs depending on the psychological variables under study, and age moderated the relation between TL and defensiveness.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.