Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
A Test of Biological and Behavioral Explanations for Gender Differences in Telomere Length: The Multi-Ethnic Study of Atherosclerosis
Belinda L. Needham,Ana Diez Roux,Chloe E. Bird,Ryan Bradley,Annette L. Fitzpatrick,David R. Jacobs,Pamela Ouyang,Teresa E. Seeman,Rebecca C. Thurston,Dhananjay Vaidya,Steven Wang +10 more
TL;DR: It was found that women had longer LTL than men, but the gender difference was smaller at older ages, and longitudinal studies are needed to assess gender differences in the rate of change in LTL over time.
Journal ArticleDOI
Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
TL;DR: It is discussed that telomere length might serve as a potential biomarker to predict the risk and prognosis of stroke and the association between leukocyte telomeres length and stroke is summarized.
Journal ArticleDOI
Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis.
Judith E. Carroll,Michael R. Irwin,Teresa E. Seeman,Ana V. Diez-Roux,Aric A. Prather,Richard G. Olmstead,Elissa S. Epel,Jue Lin,Susan Redline +8 more
TL;DR: Findings suggest that sleep apnea and sleep fragmentation are associated with accelerated biological aging.
Journal ArticleDOI
Association between polyfluoroalkyl chemical concentrations and leucocyte telomere length in US adults
TL;DR: Exposure to some environmental chemicals is reportedly associated with the leucocyte telomere length (LTL), but the effects of the non-occupational exposure to polyfluoroalkyl chemical (PFCs) on the LTL are not well understood.
Journal ArticleDOI
Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients.
Carlos Benitez-Buelga,Lara Sánchez-Barroso,Mercedes Gallardo,María Apellániz-Ruiz,L. Inglada-Pérez,Kira Yanowski,Jaime Carrillo,Laura García-Estévez,Isabel Calvo,Rosario Perona,Miguel Urioste,Ana Osorio,Maria A. Blasco,Cristina Rodríguez-Antona,Javier Benítez +14 more
TL;DR: Chemotherapy affects TL and should be considered in the studies that correlate TL with disease susceptibility, and in familial cases, only patients receiving treatment were associated with telomere shortening but they recovered normal TL after a period of 2 years.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.