Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Stress and Salivary Telomere Length in the Second Half of Life: A Comparison of Life-course Models.
TL;DR: The social trajectory model, in which the association between childhood SLEs and TL in later adulthood is fully mediated by adulthood SLES, fit the data better than the early critical period (no mediation) and cumulative risk (partial mediation) models.
Journal ArticleDOI
The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study
Anderson Sanches de Melo,Rosana Maria dos Reis,Rodrigo T. Calado,Ricardo de Carvalho Cavalli,Heloisa Bettiol,Viviane Cunha Cardoso,Rui Alberto Ferriani,Marco Antonio Barbieri,Carolina Sales Vieira +8 more
TL;DR: In this research, born SGA or AGA showed no difference in LTL shortening during a period of five years in the third decade of life, which may have implications for understanding the natural history of diseases in lifespan and its possible relation with onset of age-related diseases.
Journal ArticleDOI
Significant Shortening of Leukocyte Telomere Length in Korean Patients with Bipolar Disorder 1.
TL;DR: In this article, the authors compared the telomere length in patients with bipolar disorder (BD) with that in matched healthy controls and found significant reduction in telomeres in BD1.
Book ChapterDOI
Dietary Inflammatory Index in Ageing and Longevity
TL;DR: Both ageing and diet are able to influence the inflammatory status of the organism through the so-called “inflamm-ageing” and “metaflammation” processes, creating a constant low-grade chronic and systemic inflammation responsible for several molecular alterations.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.