Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Aberrant telomere length and mitochondrial DNA copy number in suicide completers.
Ikuo Otsuka,Takeshi Izumi,Shuken Boku,Atsushi Kimura,Yuan Zhang,Kentaro Mouri,Satoshi Okazaki,Kyoichi Shiroiwa,Motonori Takahashi,Yasuhiro Ueno,Osamu Shirakawa,Ichiro Sora,Akitoyo Hishimoto +12 more
TL;DR: This study shows the first association of aberrant telomeres and mtDNA content with suicide completion, and indicates that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.
Journal ArticleDOI
Shorter telomere length in peripheral blood leukocytes is associated with childhood autism
Zongchang Li,Jinsong Tang,Hong Li,Shan Chen,Ying He,Yanhui Liao,Zhen Wei,Guobin Wan,Xi Xiang,Kun Xia,Xiaogang Chen +10 more
TL;DR: Results provided the first evidence that shorter leukocytes telomere length is significantly associated with childhood autism, using an established real-time polymerase chain reaction method.
Journal ArticleDOI
Loving-kindness meditation slows biological aging in novices: Evidence from a 12-week randomized controlled trial
Khoa D. Le Nguyen,Jue Lin,Sara B. Algoe,Mary M. Brantley,Sumi L. Kim,Jeffrey Brantley,Sharon Salzberg,Barbara L. Fredrickson +7 more
TL;DR: This study is the first to disentangle the effects of LKM and MM on TL and suggests that LKK may buffer telomere attrition.
Journal ArticleDOI
Why are there associations between telomere length and behaviour
Melissa Bateson,Daniel Nettle +1 more
TL;DR: The selective adoption hypothesis for the association between behaviour and telomere length is both mechanistically plausible and, if anything, more compatible with existing empirical evidence than the hypothesis that behaviour is causal.
Journal ArticleDOI
Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder.
TL;DR: Key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs are explicated and the putative mechanisms by which PA mitigates these features are explored.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.