Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.
Yi Huang,Onn Siong Yim,Poh San Lai,Rongjun Yu,Soo Hong Chew,Xinyi Gwee,Ma Shwe Zin Nyunt,Qi Gao,Tze Pin Ng,Richard P. Ebstein,Richard P. Ebstein,Jean-Philippe Gouin +11 more
TL;DR: Evidence is provided that among older Singaporean Chinese with lower SES, declines in successful aging and in cognitive functioning are linked to age-related LTL shortening and hence to accelerated aging at the cellular level.
Journal ArticleDOI
Population-specific association of genes for telomere-associated proteins with longevity in an Italian population
Paolina Crocco,Roberto Barale,Giuseppina Rose,Cosmeri Rizzato,Aurelia Santoro,Francesco De Rango,Maura Carrai,Paola Fogar,Daniela Monti,Fiammetta Biondi,Laura Bucci,Rita Ostan,Federica Tallaro,Alberto Montesanto,Carlo Federico Zambon,Claudio Franceschi,Federico Canzian,Giuseppe Passarino,Daniele Campa,Daniele Campa +19 more
TL;DR: It is found that the variability of genes encoding for TERF1 and TNKS2, not directly involved in LTL, but important for keeping the integrity of the structure, shows a significant association with longevity, which suggests that the maintenance of these chromosomal structures may be critically important for preventing, or delaying, senescence and aging.
Journal ArticleDOI
Religiosity, depression and telomere length in Chinese older adults.
TL;DR: Religiosity was positively associated with TL in older mainland Chinese adults, and this association was partially mediated by depressive symptom in the 65 or older age group, which helps to explain why religiosity is related to cellular aging in older adults.
Journal ArticleDOI
Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age.
Aristidis Tsatsakis,Dimitrios Tsoukalas,Persefoni Fragkiadaki,Elena Vakonaki,Manolis Tzatzarakis,Evangelia Sarandi,Dragana Nikitovic,Gerasimos Tsilimidos,Athanasios Alegakis +8 more
TL;DR: In this article, a semi-automated worksheet, BIOTEL, was developed to generate individual and group TL statistics and provide a crude estimation of the biological age.
Journal ArticleDOI
Pregnancy as a model for aging.
TL;DR: This review will approach the connection both in respect to current theories on aging as a byproduct of natural selection, and regarding unrelated biochemical similarities between the two, drawing on existing studies and models in humans and other species where relevant alike.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.