Journal ArticleDOI
A systematic review of leukocyte telomere length and age in adults.
TLDR
While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.About:
This article is published in Ageing Research Reviews.The article was published on 2013-03-01. It has received 382 citations till now.read more
Citations
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Journal ArticleDOI
Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
Kyle Lapham,Mark N. Kvale,Jue Lin,Sheryl Connell,Lisa A. Croen,Brad Dispensa,Lynn Fang,Stephanie Hesselson,Thomas J. Hoffmann,Carlos Iribarren,Eric Jorgenson,Lawrence H. Kushi,Dana Ludwig,Tetsuya Matsuguchi,William B. McGuire,Sunita Miles,Charles P. Quesenberry,Sarah Rowell,Marianne Sadler,Lori C. Sakoda,David Smethurst,Carol P. Somkin,Stephen K. Van Den Eeden,Lawrence Walter,Rachel A. Whitmer,Pui-Yan Kwok,Neil Risch,Neil Risch,Catherine Schaefer,Elizabeth H. Blackburn +29 more
TL;DR: This study establishes reliable assay and analysis methodologies for measurement of TL in large, population-based human studies in the GERA cohort, the largest currently available such resource, linked to comprehensive electronic health and genotype data for analysis.
Journal ArticleDOI
Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y
Sonia García-Calzón,Guillermo Zalba,Miguel Ruiz-Canela,Nitin Shivappa,James R. Hébert,J. Alfredo Martínez,Montserrat Fitó,Enrique Gómez-Gracia,Miguel Ángel Martínez-González,Amelia Marti +9 more
TL;DR: The results suggest that diet might play a key role as a determinant of TL through proinflammatory or anti-inflammatory mechanisms, and both cross-sectional and longitudinal associations between the inflammatory potential of the diet and telomere shortening in subjects with a high cardiovascular disease risk.
Journal ArticleDOI
Body mass index is negatively associated with telomere length : a collaborative cross-sectional meta-analysis of 87 observational studies
Marij Gielen,Geja J. Hageman,Evangelia Antoniou,Katarina Nordfjäll,Massimo Mangino,Muthuswamy Balasubramanyam,Tim De Meyer,Audrey E. Hendricks,Audrey E. Hendricks,Erik J. Giltay,Steven C. Hunt,Jennifer A. Nettleton,Klelia D. Salpea,Vanessa A. Diaz,Ramin Farzaneh-Far,Gil Atzmon,Sarah E. Harris,Lifang Hou,David Gilley,Iiris Hovatta,Iiris Hovatta,Jeremy D. Kark,Hisham Nassar,David J. Kurz,Karen A. Mather,Peter Willeit,Yun-Ling Zheng,Sofia Pavanello,Ellen W. Demerath,Line Rode,Daniel Bunout,Andrew Steptoe,Lisa A. Boardman,Amelia Marti,Amelia Marti,Belinda L. Needham,Wei Zheng,Rosalind Ramsey-Goldman,Andrew J. Pellatt,Jaakko Kaprio,Jonathan N. Hofmann,Christian Gieger,Giuseppe Paolisso,Jacob B. H. Hjelmborg,Lisa Mirabello,Teresa E. Seeman,Jason Y.Y. Wong,Pim van der Harst,Linda Broer,Florian Kronenberg,Barbara Kollerits,Timo E. Strandberg,Daniel Eisenberg,Catherine Duggan,Josine E. Verhoeven,Roxanne Schaakxs,Raffaela Zannolli,Rosana Maria dos Reis,Fadi J. Charchar,Maciej Tomaszewski,Maciej Tomaszewski,Ute Mons,Ilja Demuth,Andrea Elena Iglesias Molli,Guo Cheng,Dmytro Krasnienkov,Bianca D’Antono,Marek Kasielski,Barry J. McDonnell,Richard P. Ebstein,Kristina Sundquist,Guillaume Paré,Michael Chong,Maurice P. Zeegers +73 more
TL;DR: In this paper, a collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and leukocyte telomere length across the life span.
Journal ArticleDOI
Maternal pre-pregnancy body mass index and newborn telomere length
Dries S. Martens,Michelle Plusquin,Michelle Plusquin,Wilfried Gyselaers,Immaculata De Vivo,Immaculata De Vivo,Tim S. Nawrot,Tim S. Nawrot +7 more
TL;DR: Maternal pre-pregnancy BMI is associated with shorter newborn telomere lengths as reflected by cord blood and placental telomeres, and these findings support the benefits of a pre-Pregnancy healthy weight for promoting molecular longevity from early life onwards.
OtherDOI
Oxidative Stress in Pulmonary Fibrosis.
TL;DR: This article discusses cellular sources of oxidant production, and antioxidant defenses, both enzymatic and nonenzymatic, and links oxidative stress to the biology of aging that involves DNA damage responses, loss of proteostasis, and mitochondrial dysfunction.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.