Advances in RSV vaccine research and development – A global agenda
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TLDR
This review summarizes current RSV vaccine research and development, including an overview of the vaccine platforms being used, the development stage of individual vaccine candidates, and gaps to be addressed to facilitate use of these vaccines to meet global health needs.About:
This article is published in Vaccine.The article was published on 2016-06-03 and is currently open access. It has received 182 citations till now. The article focuses on the topics: Palivizumab.read more
Citations
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Early-Life Origins of Chronic Obstructive Pulmonary Disease
TL;DR: The effect of early-life exposures on the lung that could lead to expiratory airflow limitation is reviewed.
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Immunosenescence and human vaccine immune responses.
TL;DR: The functional changes that are known to occur in the adaptive immune system with age are highlighted, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population.
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Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055
TL;DR: It is demonstrated that LG2055 has prophylactic potential against RSV infection and the downregulation of SRCAP induced byLG2055 could provide new insights about the inhibition of RSV replication.
Journal ArticleDOI
Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children
Eric A. F. Simões,Louis Bont,Paolo Manzoni,Brigitte Fauroux,Bosco Paes,Josep Figueras-Aloy,Paul A. Checchia,Xavier Carbonell-Estrany +7 more
TL;DR: Management of RSV remains centered around prophylaxis with the monoclonal antibody palivizumab, which has proven effective in reducing RSV hospitalization in preterm infants, children with bronchopulmonary dysplasia, and infants with hemodynamically significant congenital heart disease.
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Respiratory Syncytial Virus: The Influence of Serotype and Genotype Variability on Clinical Course of Infection.
TL;DR: Recent literature exploring genetic and molecular aspects related to RSV infection, their impact on the clinical course of the disease and their potential utility in the development of safe and effective preventive and therapeutic strategies are summarized.
References
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Journal ArticleDOI
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano,Mohsen Naghavi,Kyle J Foreman,Stephen S Lim,Kenji Shibuya,Victor Aboyans,Jerry Abraham,Tim Adair,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Suzanne Barker-Collo,David Bartels,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Kavi Bhalla,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,Fiona M. Blyth,Ian Bolliger,Soufiane Boufous,Chiara Bucello,Michael Burch,Peter Burney,Jonathan R. Carapetis,Honglei Chen,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Nabila Dahodwala,Diego De Leo,Louisa Degenhardt,Allyne Delossantos,Julie O. Denenberg,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Patricia J. Erwin,Patricia Espindola,Majid Ezzati,Valery L. Feigin,Abraham D. Flaxman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Marlene Fransen,Michael Freeman,Sherine E. Gabriel,Emmanuela Gakidou,Flavio Gaspari,Richard F. Gillum,Diego Gonzalez-Medina,Yara A. Halasa,Diana Haring,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Bruno Hoen,Peter J. Hotez,Damian G Hoy,Kathryn H. Jacobsen,Spencer L. James,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Ganesan Karthikeyan,Nicholas J Kassebaum,Andre Keren,Jon Paul Khoo,Lisa M. Knowlton,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Michael S Lipnick,Steven E. Lipshultz,Summer Lockett Ohno,Jacqueline Mabweijano,Jacqueline Mabweijano,Michael F. Macintyre,Leslie Mallinger,Lyn March,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,John J. McGrath,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Catherine Michaud,Matthew J. Miller,Ted R. Miller,Charles Mock,Ana Olga Mocumbi,Ali A. Mokdad,Andrew E. Moran,Kim Mulholland,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Kiumarss Nasseri,Paul Norman,Martin O'Donnell,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,David Phillips,Kelsey Pierce,C. Arden Pope,Esteban Porrini,Farshad Pourmalek,Murugesan Raju,Dharani Ranganathan,Jürgen Rehm,David B. Rein,G. Remuzzi,Frederick P. Rivara,Thomas Roberts,Felipe Rodriguez De Leòn,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Joshua A. Salomon,Uchechukwu Sampson,Ella Sanman,David C. Schwebel,Maria Segui-Gomez,Donald S. Shepard,David Singh,Jessica Singleton,Karen Sliwa,Emma Smith,Andrew C Steer,Jennifer A. Taylor,Bernadette Thomas,Imad M. Tleyjeh,Jeffrey A. Towbin,Thomas Truelsen,Eduardo A. Undurraga,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Theo Vos,Gregory R. Wagner,Mengru Wang,Wenzhi Wang,Kerrianne Watt,Martin A. Weinstock,Robert G. Weintraub,James D. Wilkinson,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Paul S. F. Yip,Azadeh Zabetian,Zhi Jie Zheng,Alan D. Lopez,Christopher J L Murray +195 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
Journal ArticleDOI
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
Harish Nair,Harish Nair,D. James Nokes,D. James Nokes,Bradford D. Gessner,Mukesh Dherani,Shabir A. Madhi,Rosalyn J. Singleton,Katherine L. O'Brien,Anna Roca,Anna Roca,Peter F. Wright,Nigel Bruce,Aruna Chandran,Evropi Theodoratou,Agustinus Sutanto,Endang R. Sedyaningsih,Mwanajuma Ngama,Patrick K. Munywoki,Cissy B. Kartasasmita,Eric A. F. Simões,Igor Rudan,Igor Rudan,Martin Weber,Harry Campbell +24 more
TL;DR: Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b, and the development of novel prevention and treatment strategies should be accelerated as a priority.
Journal ArticleDOI
Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine
Hyun Wha Kim,Jose G. Canchola,Carl D. Brandt,Gloria Pyles,Robert M. Chanock,Keith E. Jensen,Robert H. Parrott +6 more
Journal ArticleDOI
The burden of respiratory syncytial virus infection in young children.
Caroline B. Hall,Geoffrey A. Weinberg,Marika K. Iwane,Aaron K. Blumkin,Kathryn M. Edwards,Mary A. Staat,Peggy Auinger,Marie R. Griffin,Katherine A. Poehling,Dean D. Erdman,Carlos G. Grijalva,Yuwei Zhu,Peter G. Szilagyi +12 more
TL;DR: RSV infection is associated with substantial morbidity in U.S. children in both inpatient and outpatient settings, suggesting that control strategies targeting only high-risk children will have a limited effect on the total disease burden of RSV infection.
Journal ArticleDOI
Respiratory syncytial virus infection in elderly and high-risk adults.
Ann R. Falsey,Patricia A. Hennessey,Maria A. Formica,Christopher Cox,Edward E. Walsh,Edward E. Walsh +5 more
TL;DR: In this article, the authors evaluated all respiratory illnesses in prospective cohorts of healthy elderly patients (> or =65 years of age) and high-risk adults (those with chronic heart or lung disease) and in patients hospitalized with acute cardiopulmonary conditions.
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