Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism
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TLDR
It is suggested that SC fat is intrinsically different from VIS fat and produces substances that can act systemically to improve glucose metabolism.About:
This article is published in Cell Metabolism.The article was published on 2008-05-07 and is currently open access. It has received 611 citations till now. The article focuses on the topics: Intra-Abdominal Fat & Insulin resistance.read more
Citations
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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Markus Feuerer,Laura Herrero,Laura Herrero,Daniela Cipolletta,Afia Naaz,Jamie Wong,Jamie Wong,Ali Nayer,Jongsoon Lee,Allison B. Goldfine,Christophe Benoist,Steven E. Shoelson,Diane Mathis +12 more
TL;DR: Observations suggest that harnessing the anti-inflammatory properties of Treg cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
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The cellular and signaling networks linking the immune system and metabolism in disease
Olivia Osborn,Jerrold M. Olefsky +1 more
TL;DR: This work discusses how various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.
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Forming functional fat: a growing understanding of adipocyte differentiation
TL;DR: Improving the understanding of these mechanisms may allow us to identify therapeutic targets against metabolic diseases that are rapidly becoming epidemic globally.
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Patrick Seale,Heather M. Conroe,Jennifer L. Estall,Shingo Kajimura,Andrea Frontini,Jeff Ishibashi,Paul Cohen,Saverio Cinti,Bruce M. Spiegelman +8 more
TL;DR: It is demonstrated that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues and reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists.
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Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
References
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Ja Young Kim,Esther Van De Wall,Mathieu Laplante,Anthony Azzara,Maria E. Trujillo,Susanna M. Hofmann,Todd Schraw,Jorge L. Durand,Hua Li,Guangyu Li,Linda A. Jelicks,Mark F. Mehler,David Y. Hui,Yves Deshaies,Gerald I. Shulman,Gary J. Schwartz,Philipp E. Scherer +16 more
TL;DR: It is proposed that adiponectin acts as a peripheral "starvation" signal promoting the storage of triglycerides preferentially in adipose tissue, and reduced triglyceride levels in the liver and muscle convey improved systemic insulin sensitivity.
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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
E. Dale Abel,Odile D. Peroni,Jason K. Kim,Young-Bum Kim,Olivier Boss,Ed Hadro,Timo Minnemann,Gerald I. Shulman,Barbara B. Kahn +8 more
TL;DR: Downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes, as well as developing glucose intolerance and hyperinsulinaemia.
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Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity
Utpal B. Pajvani,Meredith Hawkins,Terry P. Combs,Michael W. Rajala,Tom Doebber,Joel P. Berger,John A. Wagner,Margaret Wu,Annemie Knopps,Anny H. Xiang,Kristina M. Utzschneider,Steven E. Kahn,Jerrold M. Olefsky,Thomas A. Buchanan,Philipp E. Scherer +14 more
TL;DR: It is demonstrated that changes in SA in a number of type 2 diabetic cohorts serve as a quantitative indicator of improvements in insulin sensitivity obtained during TZD treatment, whereas changes in total serum adiponectin levels do not correlate well at the individual level.
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A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Jens C. Brüning,M. Dodson Michael,Jonathon N. Winnay,Tatsuya Hayashi,Dieter Hörsch,Domenico Accili,Laurie J. Goodyear,C. Ronald Kahn +7 more
TL;DR: Insulin resistance in muscle contributes to the altered fat metabolism associated with type 2 diabetes, but tissues other than muscle appear to be more involved in insulin-regulated glucose disposal than previously recognized.