Journal ArticleDOI
Biological activities of HDL subpopulations and their relevance to cardiovascular disease.
TLDR
This review describes major HDL subpopulations and discusses new findings on the antiatherogenic properties of HDL particles, with the potential to reveal novel biomarkers of cardiovascular risk and new pharmacological targets.About:
This article is published in Trends in Molecular Medicine.The article was published on 2011-10-01. It has received 400 citations till now.read more
Citations
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Journal ArticleDOI
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Jan Borén,M. John Chapman,M. John Chapman,Ronald M. Krauss,Chris J. Packard,Jacob F. Bentzon,Jacob F. Bentzon,Christoph J. Binder,Mat J.A.P. Daemen,Linda L. Demer,Robert A. Hegele,Stephen J. Nicholls,Børge G. Nordestgaard,Gerald F. Watts,Gerald F. Watts,Eric Bruckert,Sergio Fazio,Brian A. Ference,Brian A. Ference,Ian D. Graham,Jay D. Horton,Ulf Landmesser,Ulrich Laufs,Luis Masana,Gerard Pasterkamp,Frederick J. Raal,Kausik K. Ray,Heribert Schunkert,Marja-Riitta Taskinen,Bart van de Sluis,Olov Wiklund,Lale Tokgozoglu,Alberico L. Catapano,Henry N. Ginsberg +33 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Journal ArticleDOI
HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Fatiha Tabet,Kasey C. Vickers,Luisa F. Cuesta Torres,Carrie B. Wiese,Bassem M. Shoucri,Gilles Lambert,Claire Catherinet,Leonel Prado-Lourenco,Michael G. Levin,Seth G. Thacker,Praveen Sethupathy,Philip J. Barter,Alan T. Remaley,Kerry-Anne Rye +13 more
TL;DR: It is demonstrated that HDL's anti-inflammatory properties are conferred, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.
Journal ArticleDOI
HDL-targeted therapies: progress, failures and future
TL;DR: The HDL hypothesis is examined in molecular and mechanistic terms, focusing on features that have been addressed, those that remain to be tested, and potential new targets for future pharmacological interventions.
Journal ArticleDOI
Cardioprotective functions of HDLs.
Kerry-Anne Rye,Philip J. Barter +1 more
TL;DR: Current understanding of the relationship of HDL subpopulations to their cardioprotective properties is summarized and gaps in current knowledge regarding this important aspect of HDL biology are highlighted.
Journal ArticleDOI
Small, Dense High-Density Lipoprotein-3 Particles Are Enriched in Negatively Charged Phospholipids Relevance to Cellular Cholesterol Efflux, Antioxidative, Antithrombotic, Anti-Inflammatory, and Antiapoptotic Functionalities
Laurent Camont,Marie Lhomme,Fabiana Rached,Wilfried Le Goff,Anne Nègre-Salvayre,Robert Salvayre,Catherine Calzada,Michel Lagarde,M. John Chapman,Anatol Kontush +9 more
TL;DR: In this article, the authors characterized the phosphosphingolipidome of major norm-lipidemic HDL subpopulations and related it to HDL functionality, using an original liquid chromatography-mass spectrometry/mass-spectrometry methodology.
References
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Journal ArticleDOI
Effects of Torcetrapib in Patients at High Risk for Coronary Events
Philip J. Barter,Mark J. Caulfield,Mats Eriksson,Scott M. Grundy,John J.P. Kastelein,Michel Komajda,Jose Lopez-Sendon,Lori Mosca,Jean-Claude Tardif,David D. Waters,Charles L. Shear,James H. Revkin,Kevin A. Buhr,Marian R. Fisher,Alan R. Tall,Bryan Brewer +15 more
TL;DR: Although there was evidence of an off-target effect of torcetrapib, it cannot rule out adverse effects related to CETP inhibition, and the trial was terminated prematurely because of an increased risk of death and cardiac events.
Journal ArticleDOI
Major lipids, apolipoproteins, and risk of vascular disease
E Di Angelantonio,Nadeem Sarwar,P Perry,Stephen Kaptoge,Kausik K. Ray,Alexander J. Thompson,Angela M. Wood,Sarah Lewington,Naveed Sattar,Chris J. Packard,Rory Collins,Simon G. Thompson,John Danesh +12 more
TL;DR: Lid assessment in vascular disease can be simplified by measurement of either total and HDL cholesterol levels or apolipoproteins without the need to fast and without regard to triglyceride.
Journal ArticleDOI
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
Journal ArticleDOI
Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL
Tomas Vaisar,Subramaniam Pennathur,Pattie S. Green,Sina A. Gharib,Andrew N. Hoofnagle,Marian C. Cheung,Jaeman Byun,Simona Vuletic,Sean Y. Kassim,Pragya Singh,Helen Chea,Robert H. Knopp,John D. Brunzell,Randolph L. Geary,Alan Chait,Xue Qiao Zhao,Keith B. Elkon,Santica M. Marcovina,Paul M. Ridker,John F. Oram,Jay W. Heinecke +20 more
TL;DR: The observations suggest that HDL plays previously unsuspected roles in regulating the complement system and protecting tissue from proteolysis and that the protein cargo of HDL contributes to its antiinflammatory and antiatherogenic properties.
Journal ArticleDOI
High Density Lipoproteins and Arteriosclerosis: Role of Cholesterol Efflux and Reverse Cholesterol Transport
TL;DR: High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs.
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