Cytokine storm induced by SARS-CoV-2.
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TLDR
The mechanisms of SARS-CoV-2-induced cytokine storm are reviewed in detail based on the current discovered researches, and some valuable medication ideas for the targeted cytokines drug researches and treatment are put forward.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-10-01 and is currently open access. It has received 389 citations till now. The article focuses on the topics: Cytokine storm & Coronavirus.read more
Citations
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Journal ArticleDOI
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.
Sarah R. Leist,Kenneth H. Dinnon,Alexandra Schäfer,Longping V. Tse,Kenichi Okuda,Yixuan J. Hou,Ande West,Caitlin E. Edwards,Wes Sanders,Ethan J. Fritch,Kendra Gully,Trevor Scobey,Ariane J. Brown,Timothy P. Sheahan,Nathaniel J. Moorman,Richard C. Boucher,Lisa E. Gralinski,Stephanie A. Montgomery,Ralph S. Baric +18 more
TL;DR: A new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice is generated and characterized to provide a robust platform for studies of ALI and ARDS to evaluate vaccine and antiviral drug performance.
Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Journal ArticleDOI
Selenium Deficiency Is Associated with Mortality Risk from COVID-19
Arash Moghaddam,Raban Arved Heller,Qian Sun,Julian Seelig,Asan Cherkezov,Linda Seibert,Julian Hackler,Petra Seemann,Joachim Diegmann,Maximilian Pilz,Manuel Bachmann,Waldemar B. Minich,Lutz Schomburg +12 more
TL;DR: It is concluded that Se status analysis in COVID patients provides diagnostic information and strengthens the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes
TL;DR: Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the extracellular environment upon fusion of multivesicular bodies and plasma membrane.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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