Deuterium magnetic resonance: theory and application to lipid membranes.
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TLDR
Proton and carbon-13 nmr spectra of unsonicated lipid bilayers and biological membranes are generally dominated by strong proton-proton and proton–carbon dipolar interactions and are rather difficult to analyse.Abstract:
Proton and carbon-13 nmr spectra of unsonicated lipid bilayers and biological membranes are generally dominated by strong proton–proton and proton–carbon dipolar interactions. As a result the spectra contain a large number of overlapping resonances and are rather difficult to analyse. Nevertheless, important information on the structure and dynamic behaviour of lipid systems has been provided by these techniques (Wennerstrom & Lindblom, 1977).read more
Citations
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Synthesis and characterization of deuterium-labelled dihexadecylglycerol and diphytanylglycerol phospholipids
Laura C. Stewart,Morris Kates +1 more
TL;DR: The chemical structures, purity and position and extent of deuterium labelling of the above compounds were established by one or more of the following techniques: TLC; 1 H, 13 C- and 2 H-NMR; CI/MS; GC; GC/MS ; and elemental analysis.
Journal ArticleDOI
Orientational anisotropy of nuclear spin relaxation in phospholipid membranes
Michael F. Brown,Olle Söderman +1 more
TL;DR: The spin-lattice relaxation rate of pure phospholipid lamellar phases depend only weakly on their orientation in the liquid-crystalline state as discussed by the authors.
Journal ArticleDOI
Effect of Trans Unsaturation on Molecular Organization in a Phospholipid Membrane
Smita P. Soni,Jennifer Runyan,Garrison Birch,Jesse A. Ward,Stephanie E. Sen,Scott E. Feller,Stephen R. Wassall +6 more
TL;DR: In this article, the authors employed solid state 2H NMR, complemented by computer simulations, to compare molecular organization in model membranes composed of 1-elaidoyl-2-stearoylphosphatidylcholine (t18:1-18:0PC), 1-oleoyl -2-threedear-lphophosphatids (c18: 1 -18: 0PC), and 1,2-distear-oyl phosphatidis (c 18:0-18 : 0PC).
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Electrostatic interactions in lecithin-bilayer systems A Monte Carlo study
TL;DR: In this paper, Monte Carlo simulations have been performed to study the electrostatic interaction between two planar zwitterionic surfaces, and the calculated lateral distribution functions and the inter-bilayer force are shown to be sensitive to the location of the dielectric discontinuities.
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Chloroquine stabilization of phospholipid membranes against diacylglycerol-induced perturbation.
TL;DR: Since SAG, endogenously formed in erythrocyte membranes, is a potent activator of phospholipase A2, this membrane-stabilizing action of chloroquine may partially account for the phosphorus-inhibiting properties of this drug, and, consequently, for both its therapeutic and toxic modes of action.
References
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Book
Principles of magnetic resonance
TL;DR: In this article, the effect of changing the precession frequency of the magnetic field has been studied using NMR to study rate properties. But the effect is limited to the case of double and double resonance.
Journal ArticleDOI
Molecular motion in spin-labeled phospholipids and membranes
Book
Spin Labeling: Theory And Applications
TL;DR: This special topics volume represents a complete update on new theoretical aspects and applications of the spin-label method and includes an IBM-compatible diskette supplied by David Schneider and Jack Freed which contains fast, accurate, ready-to-use software for slow-motion simulations.