Deuterium magnetic resonance: theory and application to lipid membranes.
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TLDR
Proton and carbon-13 nmr spectra of unsonicated lipid bilayers and biological membranes are generally dominated by strong proton-proton and proton–carbon dipolar interactions and are rather difficult to analyse.Abstract:
Proton and carbon-13 nmr spectra of unsonicated lipid bilayers and biological membranes are generally dominated by strong proton–proton and proton–carbon dipolar interactions. As a result the spectra contain a large number of overlapping resonances and are rather difficult to analyse. Nevertheless, important information on the structure and dynamic behaviour of lipid systems has been provided by these techniques (Wennerstrom & Lindblom, 1977).read more
Citations
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Locations of local anesthetic dibucaine in model membranes and the interaction between dibucaine and a Na+ channel inactivation gate peptide as studied by 2H- and 1H-NMR spectroscopies.
Yoshihiro Kuroda,M. Ogawa,H. Nasu,M. Terashima,M. Kasahara,Y. Kiyama,M. Wakita,Y. Fujiwara,Nobutaka Fujii,Terumichi Nakagawa +9 more
TL;DR: It is proposed that local anesthesia originates from the pi-stacking interaction between aromatic rings of an anesthetic molecule located at the polar headgroup region of the so-called boundary lipids and of the Phe in the intracellular linker between domains III and IV of the Na+ channel protein, prolonging the inactivated state and consequently making it impossible to proceed to the resting state.
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Study of the chromonic liquid-crystalline phases of bis-(N,N-diethylaminoethyl)perylene-3,4,9,10-tetracarboxylic diimide dihydrochloride by polarized optical microscopy and 2H NMR spectroscopy.
TL;DR: The chromonic liquid-crystalline properties of bis-(N,N-diethylaminoethyl)perylene-3,4,9,10-tetracarboxylic diimide dihydrochloride in an aqueous solution were investigated by polarized light microscopy and 2H NMR spectroscopy and the effects of temperature and concentration on the order parameter of the N phase were investigated.
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Organization of model helical peptides in lipid bilayers: insight into the behavior of single-span protein transmembrane domains.
TL;DR: Selectively deuterated transmembrane peptides comprising alternating leucine-alanine subunits were examined in fluid bilayer membranes by solid-state nuclear magnetic resonance (NMR) spectroscopy in an effort to gain insight into the behavior of membrane proteins.
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All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA.
Xiaoling Leng,Jacob J. Kinnun,Andres T. Cavazos,Samuel W. Canner,Saame Raza Shaikh,Scott E. Feller,Stephen R. Wassall +6 more
TL;DR: In this article, the plasma membrane was used as a site of action to investigate how omega-3 polyunsaturated fatty acids (n-3 PUFA) affect molecular organization when taken up into a phospholipid.
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Critical size dependence of domain formation observed in coarse-grained simulations of bilayers composed of ternary lipid mixtures
TL;DR: A critical study of system size impact on lipid domain phase separation into liquid-ordered and liquid-disordered macroscale domains in ternary lipid mixtures is presented and an analytical Flory-Huggins model is developed which is recursively validated using simulation and experimental data.
References
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Book
Principles of magnetic resonance
TL;DR: In this article, the effect of changing the precession frequency of the magnetic field has been studied using NMR to study rate properties. But the effect is limited to the case of double and double resonance.
Journal ArticleDOI
Molecular motion in spin-labeled phospholipids and membranes
Book
Spin Labeling: Theory And Applications
TL;DR: This special topics volume represents a complete update on new theoretical aspects and applications of the spin-label method and includes an IBM-compatible diskette supplied by David Schneider and Jack Freed which contains fast, accurate, ready-to-use software for slow-motion simulations.