Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer
Maha Hussain,Karim Fizazi,Fred Saad,Per Rathenborg,Neal D. Shore,Ubirajara Ferreira,Petro Ivashchenko,Eren Demirhan,Katharina Modelska,De Phung,Andrew Krivoshik,Cora N. Sternberg +11 more
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TLDR
Among men with nonmetastatic, castration‐resistant prostate cancer with a rapidly rising PSA level, enzalutamide treatment led to a clinically meaningful and significant 71% lower risk of metastasis or death than placebo.Abstract:
Background Men with nonmetastatic, castration-resistant prostate cancer and a rapidly rising prostate-specific antigen (PSA) level are at high risk for metastasis. We hypothesized that enz...read more
Citations
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Journal ArticleDOI
Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
James L. Mohler,Emmanuel S. Antonarakis,Andrew J. Armstrong,Anthony V. D'Amico,Brian J. Davis,Tanya B. Dorff,James A. Eastham,Charles Arthur Enke,Thomas A. Farrington,Celestia S. Higano,Eric M. Horwitz,Michael E. Hurwitz,Joseph E. Ippolito,Christopher J. Kane,Michael Kuettel,Joshua M. Lang,Jesse K. McKenney,George J. Netto,David F. Penson,Elizabeth R. Plimack,Julio M. Pow-Sang,Thomas J. Pugh,Sylvia Richey,Mack Roach,Stan Rosenfeld,Edward M. Schaeffer,Ahmad Shabsigh,Eric J. Small,Daniel E. Spratt,Sandy Srinivas,Jonathan D. Tward,Dorothy A. Shead,Deborah A. Freedman-Cass +32 more
TL;DR: The NCCN Guidelines for Prostate Cancer include recommendations regarding diagnosis, risk stratification and workup, treatment options for localized disease, and management of recurrent and advanced disease for clinicians who treat patients with prostate cancer.
Journal ArticleDOI
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II-2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer
Philip Cornford,Roderick C.N. van den Bergh,Erik Briers,Thomas Van den Broeck,Marcus G. Cumberbatch,Maria De Santis,Maria De Santis,Stefano Fanti,Nicola Fossati,Giorgio Gandaglia,Silke Gillessen,Nikolaos Grivas,Jeremy Grummet,Ann Henry,Theodorus H. van der Kwast,Thomas B. Lam,Thomas B. Lam,Michael Lardas,Matthew Liew,Malcolm David Mason,Lisa Moris,Daniela E. Oprea-Lager,Henk G. van der Poel,Olivier Rouvière,Ivo G. Schoots,Ivo G. Schoots,Derya Tilki,Thomas Wiegel,Peter-Paul M. Willemse,Nicolas Mottet +29 more
TL;DR: The 2020 EAU-EANM-ESTRO-ESUR-SIOG guidelines on PCa summarise the most recent findings and advice for use in clinical practice and guide the clinician in the discussion with the patient on the treatment decisions to be taken.
Journal ArticleDOI
ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer
Andrew J. Armstrong,Russell Z. Szmulewitz,Daniel P. Petrylak,Jeffrey M. Holzbeierlein,Arnauld Villers,Arun Azad,Antonio Alcaraz,Boris Alekseev,Taro Iguchi,Neal D. Shore,Brad Rosbrook,Jennifer Sugg,Benoit Baron,Lucy F. Chen,Arnulf Stenzl +14 more
TL;DR: Enzalutamide with ADT significantly reduced the risk of metastatic progression or death over time versus placebo plus ADT in men with mHSPC, including those with low-volume disease and/or prior docetaxel, with a safety analysis that seems consistent with the safety profile of enzalutamia in previous clinical trials in castration-resistant prostate cancer.
Journal ArticleDOI
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017
Silke Gillessen,Gerhardt Attard,Tomasz M. Beer,Himisha Beltran,Alberto Bossi,Robert G. Bristow,Brett S. Carver,Daniel Castellano,Byung Ha Chung,Noel W. Clarke,Gedske Daugaard,Ian D. Davis,Johann S. de Bono,Rodolfo Borges dos Reis,Charles G. Drake,Ros Eeles,Eleni Efstathiou,Christopher P. Evans,Stefano Fanti,Felix Y. Feng,Karim Fizazi,Mark Frydenberg,Martin E. Gleave,Susan Halabi,Axel Heidenreich,Celestia S. Higano,Nicolas James,Philip W. Kantoff,Pirkko-Liisa Kellokumpu-Lehtinen,Raja B. Khauli,Gero Kramer,Chris Logothetis,Fernando C. Maluf,Alicia K. Morgans,Michael J. Morris,Nicolas Mottet,Vedang Murthy,William Oh,Piet Ost,Anwar R. Padhani,Chris Parker,Colin C. Pritchard,Mack Roach,Mark A. Rubin,Charles J. Ryan,Fred Saad,Oliver Sartor,Howard I. Scher,Avishay Sella,Neal D. Shore,Matthew R. Smith,Howard R. Soule,Cora N. Sternberg,Hiroyoshi Suzuki,Christopher Sweeney,Matthew R. Sydes,Ian F. Tannock,Bertrand Tombal,Riccardo Valdagni,Thomas Wiegel,Aurelius Omlin +60 more
TL;DR: The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available.
Journal ArticleDOI
Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer
Karim Fizazi,Neal D. Shore,Teuvo L.J. Tammela,Albertas Ulys,Egils Vjaters,Sergey Polyakov,Mindaugas Jievaltas,M. Luz,Boris Alekseev,Iris Kuss,Christian Kappeler,Amir Snapir,Toni Sarapohja,Matthew R. Smith +13 more
TL;DR: Among men with nonmetastatic, castration‐resistant prostate cancer, metastasis‐free survival was significantly longer with darolutamide than with placebo and was not associated with a higher incidence of seizures, falls, fractures, cognitive disorder, or hypertension than placebo.
References
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Journal ArticleDOI
Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
Howard I. Scher,Karim Fizazi,Fred Saad,Mary-Ellen Taplin,Cora N. Sternberg,Kurt Miller,Ronald de Wit,Peter F.A. Mulders,Kim N. Chi,Neal D. Shore,Andrew J. Armstrong,Thomas W. Flaig,Aude Flechon,Paul N. Mainwaring,Mark D. Fleming,John D. Hainsworth,Mohammad Hirmand,Bryan Selby,Lynn Seely,Johann S. de Bono,B Ch +20 more
TL;DR: Enzalutamide significantly prolonged the survival of men with metastatic castration-resistant prostate cancer after chemotherapy, and was shown with respect to all secondary end points.
Journal ArticleDOI
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
Tomasz M. Beer,Andrew J. Armstrong,Dana E. Rathkopf,Yohann Loriot,Cora N. Sternberg,Celestia S. Higano,Peter Iversen,Suman Bhattacharya,Joan Carles,Simon Chowdhury,Ian D. Davis,Johann S. de Bono,Christopher P. Evans,Karim Fizazi,Anthony M. Joshua,Choung-Soo Kim,Go Kimura,Paul N. Mainwaring,Harry H. Mansbach,Kurt Miller,Sarah B. Noonberg,Frank Perabo,De Phung,Fred Saad,Howard I. Scher,Mary-Ellen Taplin,Peter Venner,Bertrand Tombal +27 more
TL;DR: Enzalutamide significantly decreased the risk of radiographic progression and death and delayed the initiation of chemotherapy in men with metastatic prostate cancer.
Journal ArticleDOI
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Chris Tran,Samedy Ouk,Nicola J. Clegg,Yu Chen,Philip A. Watson,Vivek K. Arora,John Wongvipat,Peter Smith-Jones,Dongwon Yoo,Andrew Kwon,Teresa Wasielewska,Derek S. Welsbie,Charlie D. Chen,Celestia S. Higano,Tomasz M. Beer,David T. Hung,Howard I. Scher,Michael E. Jung,Charles L. Sawyers +18 more
TL;DR: The diarylthiohydantoins RD162 and MDV3100 are characterized, two compounds optimized from a screen for nonsteroidal antiandrogens that retain activity in the setting of increased androgen receptor expression that appear to be promising candidates for treatment of advanced prostate cancer.
Journal ArticleDOI
Natural History of Progression After PSA Elevation Following Radical Prostatectomy
Charles R. Pound,Alan W. Partin,Mario A. Eisenberger,Daniel W. Chan,Jay D. Pearson,Patrick C. Walsh,Patrick C. Walsh +6 more
Journal ArticleDOI
Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer.
Matthew R. Smith,Fairooz F. Kabbinavar,Fred Saad,Arif Hussain,Marc Gittelman,David L. Bilhartz,Chris Wynne,Robin Murray,Norman Zinner,Claude Schulman,Ronald Linnartz,Ming Zheng,Carsten Goessl,Y. J. Hei,Eric J. Small,Richard J. Cook,Celestia S. Higano +16 more
TL;DR: Men with nonmetastatic prostate cancer and rising PSA despite androgen deprivation therapy have a relatively indolent natural history and baseline PSA and PSA velocity independently predict time to first bone metastasis and survival.
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