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Open AccessJournal ArticleDOI

Essential Role for Oxidative Phosphorylation in Cancer Progression

Maria Chiara Maiuri, +1 more
- 06 Jan 2015 - 
- Vol. 21, Iss: 1, pp 11-12
TLDR
It is demonstrated that only mtDNA-depleted cancer cells capable of recovering mtDNA from the host form metastasizing cancers in vivo, revealing an essential requirement for oxidative phosphorylation in tumor progression.
About: 
This article is published in Cell Metabolism.The article was published on 2015-01-06 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Tumor progression & Cancer.

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Citations
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Journal ArticleDOI

The interplay between cell signalling and the mevalonate pathway in cancer

Peter J. Mullen, +7 more
- 26 Aug 2016 - 
TL;DR: This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.
Journal ArticleDOI

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

Sil Kordes, +8 more
- 01 Jul 2015 - 
TL;DR: Addition of a conventional anti-diabetic dose of metformin does not improve outcome in patients with advanced pancreatic cancer treated with gemcitabine and erlotinib and future research should focus on patients with hyperinsulinaemia and patients with tumours showing markers of sensitivity to energetic stress.
Journal ArticleDOI

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.

Ali F. Abdel-Wahab, +3 more
- 31 Oct 2019 - 
TL;DR: This review aimed to present the most recent data on the emerging drug candidate targeting enzymes and intermediates involved in glucose metabolism to provide therapeutic opportunities and challenges for antiglycolytic cancer therapy.
Journal ArticleDOI

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

Jun Hyoung Park, +26 more
- 08 Mar 2016 - 
TL;DR: Analysis of cybrids and established breast cancer cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419, and confirmed the role of mitochondrial FAO in Src activation and metastasis.
Journal ArticleDOI

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation

Linglin Yu, +9 more
- 01 Apr 2017 - 
TL;DR: It is proposed that the hybrid phenotype contributes to metabolic plasticity, allowing cancer cells to adapt to various microenvironments, and design cancer therapies targeting metabolism.
References
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Journal ArticleDOI

Mitochondria and cancer

Douglas C. Wallace
- 01 Oct 2012 - 
TL;DR: Cancer cells then reprogramme adjacent stromal cells to optimize the cancer cell environment and activate out-of-context programmes that are important in development, stress response, wound healing and nutritional status.
Journal ArticleDOI

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Andrea Viale, +29 more
- 30 Oct 2014 - 
TL;DR: It is demonstrated that a subpopulation of dormant tumour cells surviving oncogene ablation (surviving cells) and responsible for tumour relapse has features of cancer stem cells and relies on oxidative phosphorylation for survival.
Journal ArticleDOI

Mitochondrial mutations in cancer.

Marty C. Brandon, +2 more
- 07 Aug 2006 - 
TL;DR: The mtDNA mutations in tumors may fall into two main classes: (1) severe mutations that inhibit OXPHOS, increase reactive oxygen species (ROS) and promote tumor cell proliferation and (2) milder mutations that may permit tumors to adapt to new environments.
Journal ArticleDOI

Human mitochondrial DNA: roles of inherited and somatic mutations

Eric A. Schon, +2 more
- 01 Dec 2012 - 
TL;DR: Insight into the roles of mtDNA mutations in a wide variety of diseases is discussed, highlighting the interesting genetic characteristics of the mitochondrial genome and challenges in studying its contribution to pathogenesis.
Journal ArticleDOI

Metabolic targets for cancer therapy

Lorenzo Galluzzi, +5 more
- 01 Nov 2013 - 
TL;DR: The intimate relationship between metabolism and malignancy is discussed, focusing on strategies through which this central aspect of tumour biology might be turned into cancer's Achilles heel.
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Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

An S. Tan, +25 more
- 06 Jan 2015 - 

Hallmarks of cancer: the next generation.

Douglas Hanahan, +1 more
- 04 Mar 2011 - 

A Mitochondrial Switch Promotes Tumor Metastasis

Paolo E. Porporato, +13 more
- 07 Aug 2014 - 

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Andrea Viale, +29 more
- 30 Oct 2014 - 

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

Valerie S. LeBleu, +11 more
- 01 Oct 2014 -