Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells.
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TLDR
Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure.Abstract:
Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery.read more
Citations
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Journal ArticleDOI
Targeting Tumor Microenvironment for Cancer Therapy.
TL;DR: In this article, a big effort has been made to develop new therapeutic strategies towards a more efficient targeting of tumor microenvironment (TME) components, extending from conventional therapeutics, to combined therapies and nanomedicines; and the development of models that accurately resemble the TME for bench investigations.
Journal ArticleDOI
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Tomer Cooks,Ioannis S. Pateras,Lisa M. Miller Jenkins,Keval M. Patel,Ana I. Robles,James Morris,Tim Forshew,Ettore Appella,Vassilis G. Gorgoulis,Vassilis G. Gorgoulis,Vassilis G. Gorgoulis,Curtis C. Harris +11 more
TL;DR: It is shown that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophage turns them into tumor supportive macrophages, which strongly support a microenvironmental GOF role for mut p53 in actively engaging the immune system to promote cancer progression and metastasis.
Journal ArticleDOI
Role of exosomal proteins in cancer diagnosis.
TL;DR: The recent developments in application of exosomal proteins for cancer diagnosis are summarized and can be explored for early stage cancer diagnosis, monitoring and prognosis evaluation.
Journal ArticleDOI
Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E.
Peiming Zheng,Qin Luo,Weiwei Wang,Junhua Li,Tingting Wang,Ping Wang,Lei Chen,Peng Zhang,Hui Chen,Yi Liu,Ping Dong,Guohua Xie,Yanhui Ma,Li Jiang,Xiangliang Yuan,Lisong Shen +15 more
TL;DR: It is shown that TAMs are enriched in gastric cancer and apolipoprotein E (ApoE) is highly specific and effective protein in M2 macrophages-derived exosomes, and that the exosome-mediated transfer of functional ApoE protein from TAMs to the tumor cells promotes the migration of Gastric cancer cells.
Journal ArticleDOI
Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology
Ahmed Ibrahim,Eduardo Marbán +1 more
TL;DR: What is known about exosome biogenesis, content, and transmission is summarized, with a focus on cardiovascular physiology and pathophysiology.
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