Journal ArticleDOI
Genome scale metabolic modeling of cancer
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TLDR
GEMs have great potential for translational research on cancer and will therefore become of increasing importance in the future, as they allow quantitative flux predictions using flux balance analysis (FBA).About:
This article is published in Metabolic Engineering.The article was published on 2017-09-01. It has received 87 citations till now. The article focuses on the topics: Flux balance analysis & Flux (metabolism).read more
Citations
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Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
Marc O. Johnson,Jeffrey C. Rathmell,Matthew L. Steinhauser,Aaron M. Hosios,Vivian C. Hecht,Laura V. Danai,Scott R. Manalis,Matthew G. Vander Heiden +7 more
TL;DR: This article quantified the fraction of cell mass derived from different nutrients and found that the majority of carbon mass in cells is derived from other amino acids, which are consumed at much lower rates than glucose and glutamine.
Journal ArticleDOI
Role of Glutathione in Cancer: From Mechanisms to Therapies
Luke Kennedy,Jagdeep K. Sandhu,Jagdeep K. Sandhu,Mary-Ellen Harper,Miroslava Cuperlovic-Culf,Miroslava Cuperlovic-Culf +5 more
TL;DR: Mechanisms of GSH functionalities and different therapeutic approaches that either target GSH directly, indirectly or use GSH-based prodrugs are explored.
Journal ArticleDOI
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.
Dongya Jia,Mingyang Lu,Kwang Hwa Jung,Jun Hyoung Park,Linglin Yu,José N. Onuchic,Benny Abraham Kaipparettu,Herbert Levine +7 more
TL;DR: The experimental results confirm that TNBC cells can maintain a hybrid metabolic phenotype and targeting both glycolysis and OXPHOS is necessary to eliminate their metabolic plasticity, and the theoretical framework to decode the coupling of gene regulation and metabolic pathways is established.
Journal ArticleDOI
A guide to 13C metabolic flux analysis for the cancer biologist.
TL;DR: A practical guide for investigators interested in getting started with 13C-MFA is provided, which includes best practices, pitfalls, alternative approaches, and new developments, especially new user-friendly software that allows researchers without extensive training in mathematics, statistics, or coding to perform 13C -MFA.
Journal ArticleDOI
The 2019 mathematical oncology roadmap.
Russell C. Rockne,Andrea Hawkins-Daarud,Kristin R. Swanson,Kristin R. Swanson,James P. Sluka,James P. Sluka,James A. Glazier,James A. Glazier,Paul Macklin,David A. Hormuth,Angela M. Jarrett,Ernesto A. B. F. Lima,J. Tinsley Oden,George Biros,Thomas E. Yankeelov,Kit Curtius,Ibrahim Al Bakir,Dominik Wodarz,Natalia L. Komarova,Luis Aparicio,Mykola Bordyuh,Raul Rabadan,Stacey D. Finley,Heiko Enderling,Jimmy J. Caudell,Eduardo G. Moros,Alexander R. A. Anderson,Robert A. Gatenby,Artem Kaznatcheev,Artem Kaznatcheev,Peter Jeavons,Nikhil Krishnan,Julia Pelesko,Raoul R. Wadhwa,Nara Yoon,Daniel Nichol,Andriy Marusyk,Michael Hinczewski,Jacob G. Scott +38 more
TL;DR: This Roadmap differentiates Mathematical Oncology from related fields and demonstrates specific areas of focus within this unique field of research, with the dominant theme of the personalization of medicine through mathematics, modelling, and simulation.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Regulation of cancer cell metabolism
TL;DR: Interest in the topic of tumour metabolism has waxed and waned over the past century, but it has become clear that many of the signalling pathways that are affected by genetic mutations and the tumour microenvironment have a profound effect on core metabolism, making this topic once again one of the most intense areas of research in cancer biology.
Journal ArticleDOI
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
TL;DR: It is argued that altered metabolism has attained the status of a core hallmark of cancer.
Journal ArticleDOI
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk,Matthew G. Vander Heiden,Marian H. Harris,Arvind Ramanathan,Robert E. Gerszten,Robert E. Gerszten,Ru Wei,Mark D. Fleming,Stuart L. Schreiber,Stuart L. Schreiber,Lewis C. Cantley,Lewis C. Cantley +11 more
TL;DR: It is demonstrated that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.
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