Gsh-1: a novel murine homeobox gene expressed in the central nervous system
M. Todd Valerius,Hung Li,Jeffrey L. Stock,Michael Weinstein,Satbir Kaur,Gurparkash Singh,S. Steven Potter +6 more
TLDR
The characterization of Gsh‐1, a novel murine homeobox gene, is reported, with a transcript of approximately 2 kb in size present at embryonic days 10.5 to E13.5 and the consensus DNA ninding site of the GSh‐1 homeoprotein is determined to be GCT/CA/CATTAG/A.Abstract:
We report the characterization of Gsh-1, a novel murine homeobox gene. Northern blot analysis revealed a transcript of approximately 2 kb in size present at embryonic days 10.5, 11.5, and 12.5 of development. The cDNA sequence encoded a proline rich motif, a polyalanine tract, and a homeodomain with strong homology to those encoded by the clustered Hox genes. The Gsh-1 expression pattern was determined for days E8.5 to E13.5 by whole mount and serial section in situ hybridizations. Gsh-1 transcription was restricted to the central nervous system. Expression is present in the neural tube and hindbrain as two continuous, bilaterally symmetrical stripes within neural epithelial tissue. In the mesencephalon, expression is seen as a band across the most anterior portion. There is also diencephalon expression in the anlagen of the thalamus and the hypothalamus as well as in the optic stalk, optic recess, and the ganglionic eminence. Moreover, through the use of fusion proteins containing the Gsh-1 homeodomain, we have determined the consensus DNA ninding site of the Gsh-1 homeoprotein to be GCT/CA/CATTAG/A. ©1995 Wiley-Liss, Inc.read more
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ParaHox gene expression in larval and postlarval development of the polychaete Nereis virens (Annelida, Lophotrochozoa)
TL;DR: The hypothesis that the ParaHox genes are involved in antero-posterior patterning of the developing embryo is supported, but the notion that these genes function only in the patterned of endodermal tissues is not supported.
Journal ArticleDOI
Conservation of ParaHox genes' function in patterning of the digestive tract of the marine gastropod Gibbula varia
Leyli Samadi,Gerhard Steiner +1 more
TL;DR: In Gibbula varia the ParaHox genes are expressed during anterior-posterior patterning of the digestive system, providing additional support for the ancestral complexity of Gsx expression and its ancestral role in mouth patterning in protostomes, which was secondarily lost or simplified in some species.
Journal ArticleDOI
Identification of an intact ParaHox cluster with temporal colinearity but altered spatial colinearity in the hemichordate Ptychodera flava
Tetsuro Ikuta,Tetsuro Ikuta,Yi-Chih Chen,Rossella Annunziata,Hsiu-Chi Ting,Che-Huang Tung,Ryo Koyanagi,Kunifumi Tagawa,Tom Humphreys,Asao Fujiyama,Hidetoshi Saiga,Nori Satoh,Jr-Kai Yu,Maria Ina Arnone,Yi-Hsien Su +14 more
TL;DR: The genomic organization and expression of ParaHox genes in the indirect developing hemichordate acorn worm Ptychodera flava are investigated and strongly suggest that intact ParAHox gene clustering was retained in the deuterostome ancestor and is correlated with temporal colinearity.
Journal ArticleDOI
Gsx1 expression defines neurons required for prepulse inhibition.
TL;DR: A novel genetic screen in larval zebrafish is used to reveal the molecular identity of neurons that are required for prepulse inhibition of the startle response and reveals a molecular link between control of interneuron specification and circuits that gate sensory information across brain regions.
Journal ArticleDOI
Molecular Regulation of Striatal Development: A Review
TL;DR: Early telencephalon patterning and dorsal ventral patterning are discussed with specific reference to the genes involved in striatal development, and what is known to date about the tightly controlled network of interacting genes that controlstriatal development is summarized.
References
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