A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn's Disease and Ulcerative Colitis
Ashwin N. Ananthakrishnan,Hamed Khalili,Gauree G. Konijeti,Leslie M. Higuchi,Punyanganie S. de Silva,Joshua R. Korzenik,Charles S. Fuchs,Charles S. Fuchs,Walter C. Willett,James M. Richter,Andrew T. Chan,Andrew T. Chan +11 more
TLDR
Based on data from the Nurses' Health Study, long-term intake of dietary fiber, particularly from fruit, is associated with lower risk of Crohn's disease but not UC.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 464 citations till now. The article focuses on the topics: Nurses' Health Study & Lower risk.read more
Citations
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The global burden of IBD: from 2015 to 2025
TL;DR: The goal of this article is to establish the current epidemiology of IBD in the Western world, contrast it with the increase in IBD on health-care systems in newly industrialized countries and forecast the global effects of I BD in 2025.
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Epidemiology and risk factors for IBD
TL;DR: Data support an association between smoking and Crohn's disease whereas smoking cessation, but not current smoking, is associated with an increased risk of ulcerative colitis.
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Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
Gilaad G. Kaplan,Siew C. Ng +1 more
TL;DR: This work presents a long-term plan to develop interventions that slow or stop the global increase in the incidence of IBD.
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Environmental triggers in IBD: a review of progress and evidence.
Ashwin N. Ananthakrishnan,Charles N. Bernstein,Dimitrios Iliopoulos,Andrew J. Macpherson,Markus F. Neurath,Raja Affendi Raja Ali,Stephan R. Vavricka,Claudio Fiocchi +7 more
TL;DR: Environmental factors add a substantial level of complexity to the understanding of IBD pathogenesis but also promote the fundamental notion that complex diseases such as IBD require complex therapies that go well beyond the current single-agent treatment approach.
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Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation
TL;DR: A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation.
References
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Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
Gary D. Wu,Jun Chen,Christian Hoffmann,Christian Hoffmann,Kyle Bittinger,Ying-Yu Chen,Sue A. Keilbaugh,Meenakshi Bewtra,Dan Knights,William A. Walters,Rob Knight,Rohini Sinha,Erin Gilroy,Kernika Gupta,Robert N. Baldassano,Lisa Nessel,Hongzhe Li,Frederic D. Bushman,James D. Lewis +18 more
TL;DR: Alternative enterotype states are associated with long-term diet, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella) and other enterotypes distinguished primarily by levels of Bacteroide and Prevotella.
Journal ArticleDOI
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
Carlotta De Filippo,Duccio Cavalieri,Monica Di Paola,Matteo Ramazzotti,Jean Baptiste Poullet,Sébastien Massart,Silvia Collini,Giuseppe Pieraccini,Paolo Lionetti +8 more
TL;DR: In this paper, the authors compared the fecal microbiota of European children (EU) and that of children from a rural African village of Burkina Faso (BF), where the diet, high in fiber content, is similar to that of early human settlements at the time of the birth of agriculture.
Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Reproducibility and validity of a semiquantitative food frequency questionnaire
Walter C. Willett,Walter C. Willett,Laura Sampson,Meir J. Stampfer,Meir J. Stampfer,Bernard Rosner,Chris Bain,Jelia C. Witschi,Charles H. Hennekens,Frank E. Speizer +9 more
TL;DR: Data indicate that a simple self-administered dietary questionnaire can provide useful information about individual nutrient intakes over a one-year period.
The impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and Rural Africa
Duccio Cavalieri,M. Di Paola,Matteo Ramazzotti,J.B. Poullet,Sébastien Massart,Giuseppe Pieraccini,Paolo Lionetti,C. De Filippo +7 more
TL;DR: It is hypothesized that gut microbiota coevolved with the polysaccharide-rich diet of BF individuals, allowing them to maximize energy intake from fibers while also protecting them from inflammations and noninfectious colonic diseases.
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