Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
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Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries
Makoto Kurano,Daisuke Jubishi,Koh Okamoto,Hideki Hashimoto,Eri Sakai,Yoshifumi Morita,Daisuke Saigusa,Kuniyuki Kano,Junken Aoki,Sohei Harada,Shu Okugawa,Kent Doi,Kyoji Moriya,Yutaka Yatomi +13 more
TL;DR: In this paper , the authors measured sphingolipids and glycerophospholipid (GPH) using liquid chromatography-mass spectrometry in 272 urine samples collected longitudinally from 91 COVID-19 subjects and 95 control subjects without infectious diseases, to elucidate the pathogenesis of kidney injuries.
Journal ArticleDOI
Biology and pathology of coronaviruses
TL;DR: The worldwide novel coronavirus SARS-CoV-2 pandemic is ongoing as mentioned in this paper, which can lead to dysfunctions of the lungs and other organs including the heart as already observed during SARS and MERS infections.
Posted ContentDOI
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death
Laszlo Szekely,Béla Bozóky,Matyas Bendek,Masih Ostad,Pablo Lavignasse,Lars Haag,Jieyu Wu,Xu Jing,Soham Gupta,Elisa Saccon,Anders Sönnerborg,Yihai Cao,Mikael Björnstedt,Attila Szakos +13 more
TL;DR: In this paper, the authors present twelve complete autopsies, including two rapid autopsy of young patients where the cause of death was Covid-19 ARDS, where the main virus induced pathology was in the lung parenchyma and not in the airways.
Journal ArticleDOI
Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs
Tong Wu,S. Alireza Rabi,William A. Michaud,David Becerra,Sarah E. Gilpin,Mari Mino-Kenudson,Harald C. Ott +6 more
TL;DR: In this paper , the authors used type 2 alveolar epithelial cells (AT2) derived from human iPSCs to repopulate whole rat lung acellular scaffolds and maintained them in extended biomimetic organ culture for 30 days to induce the maturation of distal lung epithelium.
Journal ArticleDOI
COVID-19 in normal, diseased and transplanted liver.
TL;DR: In this article, the authors report data regarding SARS-CoV-2 infection in subjects with normal or diseased liver, and also the risks of COVID-19 in immunosuppressed patients (either transplanted or suffering for autoimmune liver diseases) are also described.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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