Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
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SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports.
A Martín-Cardona,Josep Lloreta Trull,Raquel Albero-González,Marta Paraira Beser,Xavier Andújar,Pablo Ruiz-Ramirez,Jaume Tur-Martínez,Carme Ferrer,Jose Angel De Marcos Izquierdo,Anna Pérez-Madrigal,Laura Goiburu Gonzalez,Jorge Espinós Perez,Maria Esteve +12 more
TL;DR: In this article, the presence of SARS-CoV-2 in the physiopathology of bowel damage was confirmed by transmission electron microscopy (TEM) in two cases of severe intestinal complications (intestinal lymphoma and ischaemic colitis).
Journal ArticleDOI
Importance of Lung Epithelial Injury in COVID-19-associated Acute Respiratory Distress Syndrome: Value of Plasma Soluble Receptor for Advanced Glycation End-Products.
Natacha Kapandji,Elise Yvin,Magali Devriese,Constance de Margerie-Mellon,Giulia Moratelli,Virginie Lemiale,Matthieu Jabaudon,Elie Azoulay,Jean-Michel Constantin,Guillaume Dumas +9 more
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A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
Rachita Panda,Fernanda Vargas E Silva Castanheira,Jared Schlechte,Bas Gj Surewaard,Hanjoo Brian Shim,Amanda Z. Zucoloto,Zdenka Slavikova,Bryan G. Yipp,Paul Kubes,Braedon McDonald +9 more
TL;DR: In this article, a combination of high-dimensional single cell analysis and ex vivo functional assays of neutrophils from patients with acute respiratory distress syndrome (ARDS) compared to non-COVID ARDS (caused by bacterial pneumonia) was performed.
Posted ContentDOI
Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression
André F. Rendeiro,Joseph Casano,Charles Kyriakos Vorkas,Harjot K. Singh,Ayana Morales,Robert A. DeSimone,Grant B Ellsworth,Rosemary Soave,Shashi N Kapadia,Kohta Saito,Christopher D. Brown,Jingmei Hsu,Christopher Kyriakides,Steven Chui,Luca Vincenzo Cappelli,Maria Teresa Cacciapuoti,Wayne Tam,Lorenzo Galluzzi,Paul D. Simonson,Olivier Elemento,Mirella Salvatore,Giorgio Inghirami +21 more
TL;DR: Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity.
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Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome
David R. Price,Elisa Benedetti,Katherine Hoffman,Luis Gomez-Escobar,Sergio Alvarez-Mulett,Allyson Capili,Hina Sarwath,Christopher N. Parkhurst,Elyse LaFond,Karissa Weidman,Arjun Ravishankar,Jin-Gyu Cheong,Richa Batra,Mustafa Büyüközkan,Kelsey Chetnik,Imaani Easthausen,Edward J. Schenck,Alexandra C. Racanelli,Hasina Outtz Reed,Jeffrey Laurence,Steven Z. Josefowicz,Lindsay Lief,Mary E. Choi,Frank Schmidt,Alain C. Borczuk,Augustine M.K. Choi,Jan Krumsiek,Shahin Rafii +27 more
TL;DR: In this paper , the authors performed proteomic analysis on blood samples from COVID-19 subjects at distinct time points during acute respiratory distress syndrome (ARDS) pathogenesis (hospitalized at risk, N = 59; ARDS, n = 31; and recovery, N= 12).
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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