Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
Citations
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Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review
Vishnu Jeyalan,Joshua Storrar,Henry H.L. Wu,Arvind Ponnusamy,Smeeta Sinha,Philip A. Kalra,Rajkumar Chinnadurai +6 more
TL;DR: In this article, a systematic review of native and transplant kidney histopathological manifestations in association with COVID-19 infection was conducted, showing that kidney histological manifestations were associated with colorectal cancer.
Journal ArticleDOI
Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs
TL;DR: Current treatments including the most recent oral drugs molnupiravir and paxlovid that show a dramatic, significant efficacy in controlling severe COVID-19 infection are focused on.
Journal ArticleDOI
Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019– (COVID-19–) Associated Acute Kidney Injury
Brandon Michael Henry,Maria Helena Santos de Oliveira,Isaac Cheruiyot,Justin L. Benoit,James Rose,Emmanuel J. Favaloro,Giuseppe Lippi,Stefanie W. Benoit,Naomi Pode Shakked +8 more
TL;DR: Intravascular NETosis could be an important contributing factor in the development of microthrombosis and COVID-19-associated AKI, and therapeutic avenues for targeting this process are evaluated.
Posted ContentDOI
Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19
Ignazio S. Piras,Matthew J. Huentelman,Jessica E. Walker,Richard Arche,Michael J. Glass,Daisy Vargas,Lucia I. Sue,Anthony Intorcia,Courtney M. Nelson,Katsuko E. Suszczewicz,Claryssa Borja,Marc Desforges,Michael DeTure,Dennis Dicksond,Thomas G. Beach,Geidy E. Serrano +15 more
TL;DR: In this article, RNA sequencing on two brain regions (olfactory bulb and amygdala) from subjects who died from COVID-19 or who died of other causes was conducted, and two key genes ( CAMK2B for the synaptic neuronal network and COL1A2 for the angiogenesis/platelet activation genes) were identified.
Journal ArticleDOI
Intestinal Damage in COVID-19: SARS-CoV-2 Infection and Intestinal Thrombosis
Xiaoming Wu,Haijiao Jing,Chengyue Wang,Yufeng Wang,Nan Zuo,Tao Jiang,Valerie A. Novakovic,Jialan Shi +7 more
TL;DR: The intestinal tract, with high expression of angiotensin-converting enzyme 2 (ACE2), is a major site of extrapulmonary infection in COVID-19 and early prophylactic antithrombotic therapy can prevent these damages, thereby reducing mortality.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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