Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
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SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response.
Jessie Huang,Jessie Huang,Adam J. Hume,Kristine M. Abo,Kristine M. Abo,Rhiannon B. Werder,Rhiannon B. Werder,Carlos Villacorta-Martin,Konstantinos-Dionysios Alysandratos,Konstantinos-Dionysios Alysandratos,Mary Lou Beermann,Mary Lou Beermann,Chantelle Simone-Roach,Chantelle Simone-Roach,Jonathan Lindstrom-Vautrin,Judith Olejnik,Ellen L Suder,Esther Bullitt,Anne Hinds,Arjun Sharma,Markus Bosmann,Ruobing Wang,Ruobing Wang,Ruobing Wang,Finn Hawkins,Finn Hawkins,Eric J. Burks,Mohsan Saeed,Andrew A. Wilson,Andrew A. Wilson,Elke Mühlberger,Darrell N. Kotton,Darrell N. Kotton +32 more
TL;DR: An in vitro human model that simulates the initial apical infection of the distal lung epithelium with SARS-CoV-2 reveals the cell-intrinsic responses of a key lung target cell to infection, providing a physiologically relevant platform for further drug development and facilitating a deeper understanding of COVID-19 pathogenesis.
Journal ArticleDOI
Endothelial cells are not productively infected by SARS-CoV-2.
Lilian Schimmel,Keng Yih Chew,Claudia J. Stocks,Teodor E. Yordanov,Patricia Essebier,Arutha Kulasinghe,James Monkman,Anna Flavia Ribeiro dos Santos Miggiolaro,Caroline Cooper,Caroline Cooper,Lucia de Noronha,Kate Schroder,Anne K. Lagendijk,Larisa I. Labzin,Kirsty R. Short,Emma Gordon +15 more
TL;DR: In this paper, the authors show that primary human endothelial cells express very low levels of the SARS-CoV-2 receptor ACE2 and the protease TMPRSS2, which blocks their capacity for productive viral infection, and limits their capacity to produce infectious virus.
Journal ArticleDOI
Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective.
Francesco Fisicaro,Mario Di Napoli,Aldo Liberto,Martina Fanella,Flavio Di Stasio,Manuela Pennisi,Rita Bella,Giuseppe Lanza,Gelsomina Mansueto +8 more
TL;DR: In this article, the authors provided a preliminary description of the relationship between SARS-CoV-2 and brain sequelae, despite the limited evidence available and the heterogeneity of the studies.
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SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney.
Magen Ellen Francis,Magen Ellen Francis,Una Goncin,Andrea Kroeker,Cynthia Swan,Robyn Ralph,Robyn Ralph,Yao Lu,Athema L. Etzioni,Darryl Falzarano,Darryl Falzarano,Volker Gerdts,Steven Machtaler,Jason Kindrachuk,Jason Kindrachuk,Alyson A. Kelvin +15 more
TL;DR: This article investigated the host responses associated with infection in several major organ systems including the respiratory tract, the heart, and the kidneys after SARS-CoV-2 infection in Syrian hamsters.
Journal ArticleDOI
Cell and animal models of SARS-CoV-2 pathogenesis and immunity.
TL;DR: Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SAR's coronavirus to end the COVID-19 pandemic.
References
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Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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