Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
Citations
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Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19.
Aldo Bonaventura,Aldo Bonaventura,Alessandra Vecchié,Lorenzo Dagna,Kimberly Martinod,Dave L. Dixon,Benjamin W. Van Tassell,Francesco Dentali,Fabrizio Montecucco,Steffen Massberg,Marcel Levi,Antonio Abbate +11 more
TL;DR: In this paper, the authors proposed that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
Journal ArticleDOI
Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series.
Amy Rapkiewicz,Xingchen Mai,Steven E. Carsons,Stefania Pittaluga,David E. Kleiner,Jeffrey S. Berger,Sarun Thomas,Nicole Adler,David M. Charytan,Billel Gasmi,Judith S. Hochman,Harmony R. Reynolds +11 more
TL;DR: In this series of seven COVID-19 autopsies, thrombosis was a prominent feature in multiple organs, in some cases despite full anticoagulation and regardless of timing of the disease course, suggesting that thROMbosis plays a role very early in the disease process.
Journal ArticleDOI
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.
Sarah R. Leist,Kenneth H. Dinnon,Alexandra Schäfer,Longping V. Tse,Kenichi Okuda,Yixuan J. Hou,Ande West,Caitlin E. Edwards,Wes Sanders,Ethan J. Fritch,Kendra Gully,Trevor Scobey,Ariane J. Brown,Timothy P. Sheahan,Nathaniel J. Moorman,Richard C. Boucher,Lisa E. Gralinski,Stephanie A. Montgomery,Ralph S. Baric +18 more
TL;DR: A new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice is generated and characterized to provide a robust platform for studies of ALI and ARDS to evaluate vaccine and antiviral drug performance.
Journal ArticleDOI
A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression.
TL;DR: A timeline and correlating histopathological findings with clinical stages of COVID-19 are constructed and found to be consistent with knowledge regarding clinical patterns of viral infection, development of hyperinflammation and hypercoagulability, and fibrosis.
Journal ArticleDOI
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Jian Zheng,Lok-Yin Roy Wong,Kun Li,Abhishek Kumar Verma,M. Ortiz,Christine L. Wohlford-Lenane,Mariah R. Leidinger,C. Michael Knudson,David K. Meyerholz,Paul B. McCray,Stanley Perlman +10 more
TL;DR: Transgenic K18-hACE2 mice are a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions; infection of these mice resulted in severe pneumonia and, in some cases, infection in the brain, which was prevented by convalescent plasma.
References
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Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State.
Matt Arentz,Eric Yim,Lindy Klaff,Sharukh Lokhandwala,Francis X. Riedo,Maria Chong,Melissa Lee +6 more
TL;DR: This case series describes the clinical presentation, characteristics, and outcomes of patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit at a public hospital in Washington State in February 2020, including initial reports of cardiomyopathy in one-third of the patients.
Journal ArticleDOI
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.
Cynthia M. Magro,J. Justin Mulvey,David A. Berlin,Gerard J. Nuovo,Steven P. Salvatore,Joanna Harp,Amelia Baxter-Stoltzfus,Jeffrey Laurence +7 more
TL;DR: At least a subset of sustained, severe COVID-19 may define a type of catastrophic microvascular injury syndrome mediated by activation of complement pathways and an associated procoagulant state, and could suggest targets for specific intervention.
Journal ArticleDOI
COVID-19 pneumonia: different respiratory treatments for different phenotypes?
Luciano Gattinoni,Davide Chiumello,Pietro Caironi,Mattia Busana,Federica Romitti,Luca Brazzi,Luigi Camporota +6 more
TL;DR: It is hypothesize that the different COVID-19 patterns found at presentation in the emergency department depend on the interaction between three factors: the severity of the infection, the host response, physiological reserve and comorbidities; the ventilatory responsiveness of the patient to hypoxemia; and the time elapsed between the onset of the disease and the observation in the hospital.
Journal ArticleDOI
Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China.
Hua Su,Ming Yang,Cheng Wan,Li Xia Yi,Fang Tang,Hong Yan Zhu,Fan Yi,Haichun Yang,Agnes B. Fogo,Xiu Nie,Chun Zhang +10 more
TL;DR: In this paper, a detailed pathologic examination of kidney damage in critically ill patients with Coronavirus Disease 2019 (COVID-19) by light microscopy, ultrastructural observation and immunostaining was provided.
Journal ArticleDOI
Multiple organ infection and the pathogenesis of SARS
Jiang Gu,Encong Gong,Bo Zhang,Jie Zheng,Zifen Gao,Yan-feng Zhong,Wan-zhong Zou,Jun Zhan,Sheng-lan Wang,Zhi-gang Xie,Hui Zhuang,Bing-quan Wu,Hao-hao Zhong,Hongquan Shao,Weigang Fang,Dongshia Gao,Fei Pei,Xingwang Li,Zhongpin He,Danzhen Xu,Xeying Shi,Virginia M. Anderson,Anthony S.-Y. Leong +22 more
TL;DR: A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features and SARS virus seemed to be capable of infecting multiple cell types in several organs.
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