Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
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Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information
Halie M. Rando,Halie M. Rando,Tellen D. Bennett,James Brian Byrd,Carolyn T. Bramante,Tiffany J. Callahan,Christopher G. Chute,Hannah E. Davis,Rachel R Deer,Joel Gagnier,Farrukh M. Koraishy,Feifan Liu,Julie A. McMurry,Richard A. Moffitt,Emily R. Pfaff,Justin T. Reese,Rose Relevo,Peter N. Robinson,Joel H. Saltz,Anthony Solomonides,Anupam A Sule,Umit Topaloglu,Melissa Haendel +22 more
TL;DR: In this article, the authors investigate the definitions used in the literature published to date and compare them against data available from electronic health records and patient-reported information collected via surveys, and conclude that Long COVID holds the potential to produce a second public health crisis on the heels of the pandemic itself.
Posted ContentDOI
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C-Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Phillip Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: Increased complement activation in COVID-19 compared to influenza and non-COVID respiratory failure is reported, and alternative pathway activation is demonstrated as a key marker of multiorgan failure and death.
Journal ArticleDOI
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.
David M. Smadja,Steven J. Mentzer,Michaela Fontenay,Michael Laffan,Maximilian Ackermann,Julie Helms,Danny Jonigk,Danny Jonigk,Richard Chocron,Gerald B. Pier,Nicolas Gendron,Stéphanie Pons,Jean-Luc Diehl,Coert Margadant,Coralie L. Guerin,Coralie L. Guerin,Elisabeth J. M. Huijbers,Aurélien Philippe,Nicolas Chapuis,Patrycja Nowak-Sliwinska,Christian Karagiannidis,Olivier Sanchez,Philipp Kümpers,David Skurnik,David Skurnik,Anna M. Randi,Arjan W. Griffioen +26 more
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Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow.
TL;DR: Increasing clinical evidence shows that endothelial dysfunction is a common denominator after SARS-CoV-2 infection in the multi-organ complexity and severity of COVID-19, and replicated virus-like particles were observed enveloped in endothelial cells and lymphatic cells.
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SARS-CoV-2 organising pneumonia: 'Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?'
Pierre Kory,Jeffrey P. Kanne +1 more
TL;DR: Treatment approaches could be made more effective given that secondary OP often requires prolonged duration and/or careful and monitored tapering of corticosteroid dose, with ‘pulse’ doses needed for the well-described fulminant subtype.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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