Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
Citations
More filters
Journal ArticleDOI
Wide Spectrum of Thyroid Function Tests in COVID-19: From Nonthyroidal Illness to Isolated Hyperthyroxinemia
Sima Hashemipour,Pouria Shahsavari,Somaieh Kiani,Milad Badri,Arefeh Ghobadi,Seyyed Mohammad Reza Hadizadeh Khairkhahan,Alireza Tariverdi +6 more
TL;DR: A strong association between subclinical/overt thyrotoxicosis and AF is found and request for thyroid function test is rational in COVID-19 patients with this arrhythmia.
Journal ArticleDOI
[Systemic consequences and clinical aspects of SARS-CoV-2 infection]
Sigurd Lax,Kristijan Skok,Peter M. Zechner,Lisa Setaffy,Harald H. Kessler,Norbert Kaufmann,Klaus Vander,Natalija Cokić,Urša Maierhofer,Ute Bargfrieder,Michael Trauner +10 more
TL;DR: The most severe alterations are found in the lungs by diffuse alveolar damage as asymptom of an acute respiratory distress syndrome (ARDS), in part with fibrosis as discussed by the authors.
Journal ArticleDOI
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species
Alyssa C. Fears,Brandon J. Beddingfield,Nicole R. Chirichella,Nadia Slisarenko,Stephanie Z. Killeen,Rachel K. Redmann,Kelly Goff,Skye Spencer,Breanna Picou,Nadia A. Golden,Cecily C. Midkiff,Duane J. Bush,Luis M. Branco,Matthew L. Boisen,Hongmei Gao,David C. Montefiori,Robert V Blair,Lara A. Doyle-Meyers,Kasi E. Russell-Lodrigue,Nicholas J. Maness,Chad J. Roy +20 more
TL;DR: Demonstration of conserved pulmonary pathology regardless of species and exposure route expands understanding of how SARS-CoV-2 infection may lead to ARDS and/or functional lung damage and demonstrates the near clinical response of the nonhuman primate model for anti-fibrotic therapeutic evaluation studies.
Posted ContentDOI
Cardiac SARS-CoV-2 infection is associated with distinct transcriptomic changes within the heart
Diana Lindner,Hanna Braeuninger,Bastian Stoffers,Antonia Fitzek,Kira Meissner,Ganna Aleshcheva,Michaela Schweizer,Jessica Weimann,Bjoern Rotter,Svenja Warnke,Carolin Edler,Fabian Braun,Kevin Roedl,Katharina Scherschel,Katharina Scherschel,Felicitas Escher,Stefan Kluge,Tobias B. Huber,Benjamin Ondruschka,Heinz-Peter Schultheiss,Paulus Kirchhof,Paulus Kirchhof,Stefan Blankenberg,Klaus Pueschel,Dirk Westermann +24 more
TL;DR: In this article, the authors investigated heart tissue by in situ hybridization, immunohistochemistry and RNA sequencing in consecutive autopsy cases to quantify virus load and characterize cardiac involvement in COVID-19.
Journal ArticleDOI
Autopsy findings in COVID-19 infection-related death: a systematic review
TL;DR: The most frequent system described in autopsy findings in COVID-19 death was the respiratory system, with the most common histological finding of diffuse alveolar damage (DAD) as discussed by the authors .
References
More filters
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more