Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
Citations
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Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19.
Aldo Bonaventura,Aldo Bonaventura,Alessandra Vecchié,Lorenzo Dagna,Kimberly Martinod,Dave L. Dixon,Benjamin W. Van Tassell,Francesco Dentali,Fabrizio Montecucco,Steffen Massberg,Marcel Levi,Antonio Abbate +11 more
TL;DR: In this paper, the authors proposed that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
Journal ArticleDOI
Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series.
Amy Rapkiewicz,Xingchen Mai,Steven E. Carsons,Stefania Pittaluga,David E. Kleiner,Jeffrey S. Berger,Sarun Thomas,Nicole Adler,David M. Charytan,Billel Gasmi,Judith S. Hochman,Harmony R. Reynolds +11 more
TL;DR: In this series of seven COVID-19 autopsies, thrombosis was a prominent feature in multiple organs, in some cases despite full anticoagulation and regardless of timing of the disease course, suggesting that thROMbosis plays a role very early in the disease process.
Journal ArticleDOI
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.
Sarah R. Leist,Kenneth H. Dinnon,Alexandra Schäfer,Longping V. Tse,Kenichi Okuda,Yixuan J. Hou,Ande West,Caitlin E. Edwards,Wes Sanders,Ethan J. Fritch,Kendra Gully,Trevor Scobey,Ariane J. Brown,Timothy P. Sheahan,Nathaniel J. Moorman,Richard C. Boucher,Lisa E. Gralinski,Stephanie A. Montgomery,Ralph S. Baric +18 more
TL;DR: A new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice is generated and characterized to provide a robust platform for studies of ALI and ARDS to evaluate vaccine and antiviral drug performance.
Journal ArticleDOI
A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression.
TL;DR: A timeline and correlating histopathological findings with clinical stages of COVID-19 are constructed and found to be consistent with knowledge regarding clinical patterns of viral infection, development of hyperinflammation and hypercoagulability, and fibrosis.
Journal ArticleDOI
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Jian Zheng,Lok-Yin Roy Wong,Kun Li,Abhishek Kumar Verma,M. Ortiz,Christine L. Wohlford-Lenane,Mariah R. Leidinger,C. Michael Knudson,David K. Meyerholz,Paul B. McCray,Stanley Perlman +10 more
TL;DR: Transgenic K18-hACE2 mice are a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions; infection of these mice resulted in severe pneumonia and, in some cases, infection in the brain, which was prevented by convalescent plasma.
References
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Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.
Jing Liu,Sumeng Li,Jia Liu,Boyun Liang,Xiaobei Wang,Hua Wang,Wei Li,Qiaoxia Tong,Jianhua Yi,Lei Zhao,Lijuan Xiong,Chunxia Guo,Jin Tian,Jinzhuo Luo,Jinghong Yao,Ran Pang,Hui Shen,Cheng Peng,Ting Liu,Qian Zhang,Jun Wu,Ling Xu,Sihong Lu,Baoju Wang,Zhihong Weng,Chunrong Han,Huabing Zhu,Ruxia Zhou,Helong Zhou,Xiliu Chen,Pian Ye,Bin Zhu,Lu Wang,Wenqing Zhou,Shengsong He,Yong-Wen He,Shenghua Jie,Ping Wei,Jianao Zhang,Yinping Lu,Weixian Wang,Li Zhang,Ling Li,Fengqin Zhou,Jun Wang,Jun Wang,Ulf Dittmer,Ulf Dittmer,Mengji Lu,Mengji Lu,Yu Hu,Dongliang Yang,Xin Zheng +52 more
TL;DR: The degree of lymphopenia and a proinflammatory cytokine storm is higher in severe COVID-19 patients than in mild cases, and is associated with the disease severity.
Journal ArticleDOI
Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer.
TL;DR: Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells, which likely represent an early phase of the lung pathology of COVID-19 pneumonia.
Journal ArticleDOI
Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington.
Temet M. McMichael,Dustin W Currie,Shauna Clark,Sargis Pogosjans,Meagan Kay,Noah G. Schwartz,James S. Lewis,Atar Baer,Vance Kawakami,Margaret D. Lukoff,Jessica Ferro,Claire Brostrom-Smith,Thomas D. Rea,Michael R. Sayre,Francis X. Riedo,Denny Russell,Brian Hiatt,Patricia Montgomery,Agam K Rao,Eric J. Chow,Farrell A Tobolowsky,Michael J. Hughes,Ana C Bardossy,Lisa P. Oakley,Jesica R. Jacobs,Nimalie D. Stone,Sujan C. Reddy,John A. Jernigan,John A. Jernigan,Margaret A. Honein,Thomas A. Clark,Jeffrey S. Duchin +31 more
TL;DR: In this paper, the authors proposed that long-term care facilities are high-risk settings for severe outcomes from outbreaks of Covid-19, owing to both the advanced age and frequent chronic underlying health conditions.
Journal ArticleDOI
Lung pathology of fatal severe acute respiratory syndrome
John M. Nicholls,Leo L.M. Poon,Kam Cheong Lee,Wai F. Ng,Sik T. Lai,Chung Y. Leung,Chung M. Chu,Pak K. Hui,K.L. Mak,Wilina Lim,Kin W. Yan,Kwok H. Chan,Ngai C. Tsang,Yi Guan,Kwok-Yung Yuen,J. S. Peiris +15 more
TL;DR: The presence of haemophagocytosis supports the contention that cytokine dysregulation may account, at least partly, for the severity of the clinical disease.
Journal ArticleDOI
Management of COVID-19 Respiratory Distress.
John J. Marini,Luciano Gattinoni +1 more
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