Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
Citations
More filters
Posted ContentDOI
The maladaptive vascular response in COVID-19 acute respiratory distress syndrome and recovery
David R. Price,Elisa Benedetti,Katherine Hoffman,Luis Gomez-Escobar,Sergio Alvarez-Mulett,Allyson Capili,Hina Sarwath,Christopher N. Parkhurst,Elyse LaFond,Karissa Weidman,Arjun Ravishankar,Jin Gyu Cheong,Richa Batra,Mustafa Buyukozkan,Kelsey Chetnik,Imaani Easthausen,Edward J. Schenck,Alexandra C. Racanelli,Hasina Outtz Reed,Jeffrey Laurence,Jeffrey Laurence,Steven Z. Josefowicz,Lindsay Lief,Mary E. Choi,Mary E. Choi,Shahin Rafii,Shahin Rafii,Frank Schmidt,Alain C. Borczuk,Jan Krumsiek,Augustine M.K. Choi +30 more
TL;DR: In this article, the authors used lung autopsy immunohistochemistry and blood proteomics from COVID-19 subjects at distinct timepoints in disease pathogenesis, including a hospitalized cohort at risk of acute respiratory distress syndrome (ARDS), an intensive care unit cohort with ARDS, and a cohort recovering from ARDS ("recovery", N=12).
Journal ArticleDOI
Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2
George Ssenyange,Maya Kerfoot,Min Zhao,Shelli F. Farhadian,Sidi Chen,Lei Peng,Ping Ren,Charles S. Dela Cruz,Shaili Gupta,Richard E. Sutton +9 more
TL;DR: In this article , the authors developed a SARS-CoV-2 cell-cell transmission assay that provides a rapid and quantitative readout to assess SARS and CoV2 spike hACE2 interaction in the absence of pseudotyped particles or live virus.
Posted ContentDOI
Clinico-pathological features in fatal Covid-19 Infection: A Preliminary Experience of a Tertiary Care Centre in North India using Post-Mortem Minimally Invasive Tissue Biopsies
Animesh Ray,Deepali Jain,Shubham Agarwal,Shekhar Swaroop,Ayush Goel,Prasenjit Das,Sudheer Arava,Asit Ranjan Mridha,Aruna Nambirajan,Geetika Singh,S. Arulselvi,Purva Mathur,S. Kumar,Shubham Sahni,Jagbir Nehra,Nazneen,Mouna Bm,Neha Rastogi,Sandeep Mahato,Chaavi Gupta,S Bharadhan,Gaurav Dhital,Pawan Goel,Praful Pandey,Santosh Kn,Shitij Chaudhary,Vishakh C Keri,Vishal Singh Chauhan,Niranjan Mahishi,Anand Shahi,Ragu R,Baidnath K Gupta,Richa Aggarwal,Kapil Dev Soni,Neeraj Nischal,Manish Soneja,Sanjeev Lalwani,Chitra Sarkar,Randeep Guleria,Naveet Wig,Anjan Trikha +40 more
TL;DR: The most common finding in this cohort is the diffuse alveolar damage with demonstration of SARS-CoV-2 protein in the acute phase of DAD, which suggests that liver might be a primary target of Covid-19.
Journal ArticleDOI
Liver pathology in COVID-19 related death and leading role of autopsy in the pandemic
Martina Zanon,Margherita Neri,Stefano Pizzolitto,Davide Radaelli,Monica Concato,Michela Peruch,Stefano D'Errico +6 more
TL;DR: A literature review revealed that pre-existing liver disease and elevation of liver enzyme in these patients are not common; liver enzyme elevations tend to be seen in those in critical conditions as discussed by the authors .
Journal ArticleDOI
COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
A. R. Santa Cruz,Flávio P. Veras,Ronaldo B. Martins,Rafaella Stradiotto Bernardelli,Isadora Marques Paiva,Thais Martins de Lima,Youvika Singh,Raphael C. Guimarães,Samara Damasceno,Nayara Gonçalves Pereira,João Manoel Alves,Tiago T. Gonçalves,Julia Forato,Stéfanie Primon Muraro,Gabriela Fabiano de Souza,Sabrina Setembre Batah,José Luiz Proença-Módena,Marcelo A. Mori,Fernando Q. Cunha,Paulo Louzada-Junior,Thiago M. Cunha,Helder I. Nakaya,Alexandre Todorovic Fabro,Renê Donizeti Ribeiro de Oliveira,Eurico Arruda,Rosangela Rea,Álvaro Rea Neto,Miguel Morita Fernandes da Silva,Luiz O. Leiria +28 more
TL;DR: In this paper , the authors found that COVID-19 is independently associated with in-hospital hyperglycemia and that SARS-CoV-2 is capable of infecting hepatocytes and stimulate these cells to produce glucose through gluconeogenesis.
References
More filters
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more