Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TLDR
In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.About:
This article is published in The Lancet.The article was published on 2020-08-01 and is currently open access. It has received 587 citations till now. The article focuses on the topics: Diffuse alveolar damage & Kidney disease.read more
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SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence.
Sameer Mohammad,Abderrezak Bouchama,Bothina Mohammad Alharbi,Mamoon Rashid,Tanveer Saleem Khatlani,Nusaibah S. Gaber,Shuja Shafi Malik +6 more
TL;DR: There appears to be significant structural integrity and functional proximity between these proteins pointing towards their high significance, and there is further need for comprehensive genomics and structural-functional studies to lead towards definitive conclusions regarding their criticality.
Journal ArticleDOI
Cardiovascular Manifestations and Mechanisms in Patients with COVID-19.
TL;DR: This study systematically reviews cardiovascular manifestations, histopathology, and mechanisms of COVID-19 to help formulate future research goals and facilitate the development of therapeutic management strategies.
Journal ArticleDOI
High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data.
Luis Antonio Díaz,Francisco Idalsoaga,Macarena Cannistra,Roberto Candia,Daniel Cabrera,Francisco Barrera,Alejandro Soza,Rondell P. Graham,Arnoldo Riquelme,Marco Arrese,Michael D. Leise,Juan Pablo Arab +11 more
TL;DR: In this paper, a systematic review with meta-analysis registered on PROSPERO (CRD42020192813), following PRISMA guidelines, was conducted to characterize hepatic pathological findings in patients with COVID-19.
Journal ArticleDOI
Persistent Symptoms in Patients Recovering From COVID-19 in Denmark
Steffen Leth,Jesper Damsgaard Gunst,Jesper Damsgaard Gunst,Victor Dahl Mathiasen,Kristoffer Skaalum Hansen,Ole Schmeltz Søgaard,Ole Schmeltz Søgaard,Lars Østergaard,Lars Østergaard,Søren Jensen-Fangel,Merete Storgaard,Jane Agergaard +11 more
TL;DR: In this paper, patients with positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 who were hospitalized at the Department of Infectious Diseases, Aarhus University Hospital, Denmark, in the period from March 11 to May 15 were offered follow-up after hospitalization On admission, a comprehensive symptom and medical history was collected, including demographic characteristics, duration of symptoms, comorbidities, and concomitant medications.
Journal ArticleDOI
Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection
Ivo M.B. Francischetti,Kevin Toomer,Yifan Zhang,Jayesh Jani,Zishan K. Siddiqui,Daniel J. Brotman,Jody E. Hooper,Thomas S. Kickler +7 more
TL;DR: In this article, the cause of coagulopathy in SARS-CoV-2 infection is incompletely understood and a single-center cross-sectional study including 66 adult COVID-19 patients (40 moderate, 26 severe disease, and 9 controls, performed between 04/2020 and 10/2020.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
TL;DR: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for d
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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