Human dendritic cell subsets.
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TLDR
Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.Abstract:
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.read more
Citations
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Dendritic Cells, the Double Agent in the War Against HIV-1.
TL;DR: The current state of knowledge on how both DC subsets (myeloid and plasmacytoid DCs) act in presence of HIV-1 is summarized, and different pathways that the virus can take after binding to DC are focused on.
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The human spleen as the center of the blood defense system.
TL;DR: The structure of the spleen is introduced in this review in relation to its function in the BDS as part of the response of the immune system and of functioning organs to blood-borne pathogens.
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Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells.
TL;DR: The literature data concerning MSC-derived EVs is discussed, including the current standardized methods for their isolation and characterization, the mechanisms supporting their immunoregulatory properties, and their potential clinical application as alternative to M SC-based therapy for inflammatory reactions, such as graft-versus-host disease (GvHD).
Journal ArticleDOI
Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors
Patrizia Stoitzner,Sandra Schaffenrath,Christoph H. Tripp,Daniela Reider,Kerstin Komenda,Barbara Del Frari,Gabriel Djedovic,Susanne Ebner,Nikolaus Romani +8 more
TL;DR: It is demonstrated that LC can be preferentially targeted by Langerin mAb, and the efficacy of DEC‐205 mAb targeting strategy can be boosted by addition of poly I:C underlining the potential of this combination for immunotherapeutical interventions.
Journal ArticleDOI
Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases.
TL;DR: This review summarizes the current available information regarding human intestinal DC subsets composition, phenotype, and function in the human gastrointestinal tract describing how, in the IBD mucosa, DC display pro-inflammatory properties, which drive disease progression.
References
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Journal ArticleDOI
The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
Journal ArticleDOI
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
TL;DR: The present document proposes a nomenclature for monocytes and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendrites) in human and in mouse blood.
Journal ArticleDOI
Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Journal ArticleDOI
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Journal ArticleDOI
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.
Marina Cella,David Jarrossay,Fabio Facchetti,Olga Alebardi,Hideo Nakajima,Antonio Lanzavecchia,Marco Colonna +6 more
TL;DR: Results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon.
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Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more