Human dendritic cell subsets.
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TLDR
Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.Abstract:
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.read more
Citations
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HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
Andrew T. Jones,Andrew T. Jones,Xiaoying Shen,Korey L. Walter,Celia C. LaBranche,Linda S. Wyatt,Georgia D. Tomaras,David C. Montefiori,Bernard Moss,Dan H. Barouch,John D. Clements,Pamela A. Kozlowski,Raghavan Varadarajan,Rama Rao Amara,Rama Rao Amara +14 more
TL;DR: It is shown that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.
Journal ArticleDOI
The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver--a systematic review.
TL;DR: It was apparent that further research is now required to accurately characterize the cells of the MPS in human liver, using modern immunological techniques, as neither liver dendritic cell subsets nor macrophages have been thoroughly characterized.
Journal ArticleDOI
The Role of Myeloid-Derived Cells in the Progression of Liver Disease.
TL;DR: The role of myeloid cells in the establishment and progression of liver disease is reviewed and key pathways that have become the focus for current and future therapeutic strategies are highlighted.
Journal ArticleDOI
Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV.
Marta Rodriguez-Garcia,Zheng Shen,Fiona D. Barr,Austin W. Boesch,Margaret E. Ackerman,John C. Kappes,Christina Ochsenbauer,C.R. Wira +7 more
TL;DR: The results suggest that specific DC subsets in the FRT have the potential for capture and dissemination of HIV, exert antiviral responses and likely contribute to the recruitment of HIV-target cells through the secretion of innate immune molecules.
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Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry
TL;DR: A modular assay for the detailed immunophenotyping of blood (DIoB) that was optimized for an easy and direct application in whole blood samples and might pave the way for immune biomarker identification for prediction and prognosis of therapy outcome.
References
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Journal ArticleDOI
The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
Journal ArticleDOI
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
TL;DR: The present document proposes a nomenclature for monocytes and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendrites) in human and in mouse blood.
Journal ArticleDOI
Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Journal ArticleDOI
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Journal ArticleDOI
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.
Marina Cella,David Jarrossay,Fabio Facchetti,Olga Alebardi,Hideo Nakajima,Antonio Lanzavecchia,Marco Colonna +6 more
TL;DR: Results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon.
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Nomenclature of monocytes and dendritic cells in blood.
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