Human dendritic cell subsets.
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TLDR
Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.Abstract:
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.read more
Citations
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Journal ArticleDOI
Dendritic Cells Currently under the Spotlight; Classification and Subset Based upon New Markers.
TL;DR: This review focus on the most common subsets of DCs in human, generally separated into the blood and cutaneous subsets, mainly because these parts are more comfortable to examine in humans.
Journal ArticleDOI
Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation.
Elisabeth M S Beijnen,Elisabeth M S Beijnen,Elisabeth M S Beijnen,Simon D. van Haren,Simon D. van Haren +4 more
TL;DR: A review of the literature pertaining to the frequency and phenotype of newborn and infant CD8+ T cells, and any evidence of induction of T cells by currently licensed pediatric vaccine formulations can be found in this article.
Journal ArticleDOI
Interferon-α-Induced Dendritic Cells Generated with Human Platelet Lysate Exhibit Elevated Antigen Presenting Ability to Cytotoxic T Lymphocytes.
Ippei Date,Terutsugu Koya,Takuya Sakamoto,Misa Togi,Haruhiko Kawaguchi,Asuka Watanabe,Tomohisa Kato,Shigetaka Shimodaira +7 more
TL;DR: In this article, the potential ability of human platelet lysate (HPL) to produce interferon-α-induced dendritic cells (IFN-DCs) was evaluated.
Journal ArticleDOI
Analysis of the immune response of human dendritic cells to Mycobacterium tuberculosis by quantitative proteomics.
Chiu-Ping Kuo,Kuo-Song Chang,Jue-Liang Hsu,I-Fang Tsai,Andrew Boyd Lin,Tsai-Yin Wei,Chien-Liang Wu,Yen-Ta Lu,Yen-Ta Lu +8 more
TL;DR: It is demonstrated that the highly-expressed CD13 is also associated with proteins involved in the antigen presenting process, especially with CD1 proteins, as well as in the pathogenesis of M. tuberculosis.
Book ChapterDOI
Dendritic Cells in the Tumor Microenvironment.
Karan Kohli,Venu G. Pillarisetty +1 more
TL;DR: This chapter discusses various aspects of DC development and function and discusses how various tumor microenvironments can affect DC development, function, and migration, thus evading a strong adaptive immune response.
References
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Journal ArticleDOI
The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
Journal ArticleDOI
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
TL;DR: The present document proposes a nomenclature for monocytes and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendrites) in human and in mouse blood.
Journal ArticleDOI
Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Journal ArticleDOI
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Journal ArticleDOI
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.
Marina Cella,David Jarrossay,Fabio Facchetti,Olga Alebardi,Hideo Nakajima,Antonio Lanzavecchia,Marco Colonna +6 more
TL;DR: Results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon.
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Dendritic cells and the control of immunity
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more