Human dendritic cell subsets.
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TLDR
Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.Abstract:
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.read more
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Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells.
TL;DR: Poly(I:C)-matured moDCs are the most effective conventional DC subtype for generating a functionally competent NK-cell repertoire by an IL12p70-dependent mechanism, and results in a dominant, multifunctional, NKG2Apos NK- cell population that is capable of both cytolysis and IFNγ production.
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Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis.
TL;DR: This work has shown that RNA-based drugs formulated as lipid nanoparticles (LNP) can open new avenues for the personalized treatment of liver fibrosis both through specific interference and via the induction of the expression of functional and therapeutic proteins.
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Green Tea Polyphenol Epigallocatechine Gallate (EGCG) Prevented LPS- induced BV-2 Micoglial Cell Activation
Euteum Park,Hong Sung Chun +1 more
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A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study
Madusha Peiris,Zsa Zsa R. M. Weerts,Rubina Aktar,Ad A.M. Masclee,Ashley Blackshaw,Daniel Keszthelyi +5 more
TL;DR: In this article, transient receptor potential melastatin 8 (TRPM8) agonists, such as L-menthol in peppermint oil, have shown to attenuate IBS pain symptoms.
References
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Journal ArticleDOI
The nature of the principal type 1 interferon-producing cells in human blood.
Frederick P. Siegal,Norimitsu Kadowaki,Michael Shodell,Patricia Fitzgerald-Bocarsly,Kokila Shah,Stephen Ho,Svetlana Antonenko,Yong-Jun Liu +7 more
TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
Journal ArticleDOI
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
TL;DR: The present document proposes a nomenclature for monocytes and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendrites) in human and in mouse blood.
Journal ArticleDOI
Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Journal ArticleDOI
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Journal ArticleDOI
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.
Marina Cella,David Jarrossay,Fabio Facchetti,Olga Alebardi,Hideo Nakajima,Antonio Lanzavecchia,Marco Colonna +6 more
TL;DR: Results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon.
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Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more