Human dendritic cell subsets.
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TLDR
Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.Abstract:
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.read more
Citations
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The Tumor Microenvironment Innately Modulates Cancer Progression
TL;DR: Cross-talk between cancer cells and the proximal immune cells ultimately results in an environment that fosters tumor growth and metastasis, and understanding the nature of this dialog will allow for improved therapeutics that simultaneously target multiple components of the TME, increasing the likelihood of favorable patient outcomes.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
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Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.
Jean-François Emile,Oussama Abla,Sylvie Fraitag,AnnaCarin Horne,Julien Haroche,Jean Donadieu,Luis Requena-Caballero,Michael B. Jordan,Omar Abdel-Wahab,Carl E. Allen,Frédéric Charlotte,Eli L. Diamond,R. Maarten Egeler,Alain Fischer,Alain Fischer,Juana Gil Herrera,Jan-Inge Henter,Filip Janku,Miriam Merad,Jennifer Picarsic,Carlos Rodriguez-Galindo,Barret J. Rollins,Barret J. Rollins,Abdellatif Tazi,Robert Vassallo,Lawrence M. Weiss +25 more
TL;DR: This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocyts and macrophage activation syndrome.
Journal ArticleDOI
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams,Martin Guilliams,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Charlotte L. Scott,Naomi McGovern,Dorine Sichien,Svetoslav Chakarov,Sofie Van Gassen,Jinmiao Chen,Michael Poidinger,Sofie De Prijck,Simon Tavernier,Ivy Low,Sergio Erdal Irac,Citra Nurfarah Zaini Mattar,Hermi Sumatoh,Gillian Low,Tam John Kit Chung,Dedrick Kok Hong Chan,Ker-Kan Tan,Tony Lim Kiat Hon,Even Fossum,Bjarne Bogen,Mahesh Choolani,Jerry Kok Yen Chan,Anis Larbi,Hervé Luche,Sandrine Henri,Yvan Saeys,Evan W. Newell,Bart N. Lambrecht,Bart N. Lambrecht,Bernard Malissen,Florent Ginhoux +34 more
TL;DR: A universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues is provided and validated.
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Dendritic cell-based immunotherapy
TL;DR: What has been learned thus far about human DC biology from clinical studies are discussed, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity are discussed.
References
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Journal ArticleDOI
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
TL;DR: Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen, and migrated across the endot Helium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
Journal ArticleDOI
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
Annabell Bachem,Steffen Güttler,Evelyn Hartung,Frédéric Ebstein,Michael Schaefer,Astrid Tannert,Abdulgabar Salama,Kamran Movassaghi,Corinna Opitz,Hans W. Mages,Volker Henn,Peter-Michael Kloetzel,Stephanie Gurka,Richard A. Kroczek +13 more
TL;DR: It is shown that CD141+ DCs are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis and defined as professional antigen cross-presenting DCs in the human.
Journal ArticleDOI
Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen
Maud Plantinga,Martin Guilliams,Martin Guilliams,Manon Vanheerswynghels,Kim Deswarte,Filipe Branco-Madeira,Wendy Toussaint,Leen Vanhoutte,Leen Vanhoutte,Katrijn Neyt,Nigel Killeen,Bernard Malissen,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht +14 more
TL;DR: Migratory CD11b(+) cDCs are identified as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung.
Journal ArticleDOI
Characterization of human blood dendritic cell subsets.
Kelli P. A. MacDonald,D.J. Munster,Georgina J Clark,Andrzej Dzionek,Juergen Schmitz,Derek Nigel John Hart +5 more
TL;DR: The poor viability of CD123(-) DCs in vitro was confirmed, but the CD16(+) CD11c(+) DC subset also survived poorly, and these data provide an opportunity to standardize the DC populations used for future molecular, functional and possibly even therapeutic studies.
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