Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Cerebrospinal Fluid Biomarkers and Rate of Cognitive Decline in Very Mild Dementia of the Alzheimer Type
Barbara J. Snider,Anne M. Fagan,Catherine M. Roe,Aarti R. Shah,Elizabeth A. Grant,Chengjie Xiong,John C. Morris,David M. Holtzman +7 more
TL;DR: In individuals with very mild DAT, lower CSF Abeta 42 levels, higher tau or ptau181 levels, or high tau:Abeta 42 ratios quantitatively predict more rapid progression of cognitive deficits and dementia.
Journal ArticleDOI
Imaging Approaches to Parkinson Disease
TL;DR: The role of structural and functional imaging for diagnosing and managing different parkinsonian syndromes is discussed and the use of dopaminergic medications is rationalized.
Journal ArticleDOI
Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.
Suzanne E. Schindler,Julia D. Gray,Brian A. Gordon,Chengjie Xiong,Richard Batrla-Utermann,Marian Quan,Simone Wahl,Tammie L.S. Benzinger,David M. Holtzman,John C. Morris,Anne M. Fagan +10 more
TL;DR: The relationship between CSF biomarkers, as measured by a novel automated immunoassay platform, and amyloid positron emission tomography is examined.
Journal ArticleDOI
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.
Clifford R. Jack,Michael Garwood,Thomas M. Wengenack,Bret J. Borowski,Geoffrey L. Curran,Joseph Lin,Gregor Adriany,Olli Gröhn,Olli Gröhn,Roger C. Grimm,Joseph F. Poduslo +10 more
TL;DR: This work represents the first demonstration of noninvasive in vivo visualization of individual AD plaques without the use of a contrast agent, and results indicate that a spin echo acquisition more accurately reflects plaque size, while a T2* weighted gradient echo sequence reflects plaque iron content, not plaque size.
Journal ArticleDOI
Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study
Hilary Archer,Paul Edison,David J. Brooks,Josephine Barnes,Chris Frost,Tom Yeatman,Nick C. Fox,Martin N. Rossor +7 more
TL;DR: A positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional 11C‐PIB uptake provides support for the central role of amyloid deposition in the pathogenesis of AD.
References
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Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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Phases of Aβ-deposition in the human brain and its relevance for the development of AD
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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