Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
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Journal ArticleDOI
Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design.
Arno de Wilde,Ingrid S. van Maurik,Marleen Kunneman,Femke H. Bouwman,Marissa D. Zwan,Eline A.J. Willemse,Geert Jan Biessels,Mirella Minkman,Ruth Pel,Niki S.M. Schoonenboom,Ellen M. A. Smets,Mike P. Wattjes,Frederik Barkhof,Andrew Stephens,Erik van Lier,Richard Batrla-Utermann,Philip Scheltens,Charlotte E. Teunissen,Bart N.M. van Berckel,Wiesje M. van der Flier +19 more
TL;DR: The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests to daily clinical practice with a focus on mild cognitive impairment (MCI).
Journal ArticleDOI
18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.
Christopher C. M. Lee,Heidi I.L. Jacobs,Marta Marquié,John A. Becker,Nicolas V Andrea,David S. Jin,Aaron P. Schultz,Matthew P. Frosch,Teresa Gomez-Isla,Reisa A. Sperling,Keith A. Johnson +10 more
TL;DR: Melanocyte FTP binding may account partially for high CP signal, and this off-target binding affects mainly HC FTP measurements, which should be interpreted with caution.
Journal ArticleDOI
Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)
Dewen Yang,Zhiyong Xie,Diane Stephenson,Daniel Morton,Carol D. Hicks,Tracy M. Brown,Renuka Sriram,Sharon M. O’Neill,David Raunig,Thomas M.A. Bocan +9 more
TL;DR: In vivo MRI/S can be a non-invasive biomarker to assess brain atrophy and related biochemical changes in the rTg4510 mouse model and assessment revealed that the myo-inositol to total creatine ratios (mIns/tCr), a measure of gliosis, were significantly higher in the hippocampus of rTG4510 mice relative to wt mice.
Journal ArticleDOI
The role of neuroimaging in elucidating delirium pathophysiology.
David C. Alsop,Michael A. Fearing,Keith A. Johnson,Reisa A. Sperling,Tamara G. Fong,Sharon K. Inouye +5 more
TL;DR: A review of the current literature of imaging studies in delirium and related conditions, introduces some of the newer capabilities of neuroimaging with magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography as mentioned in this paper.
Journal ArticleDOI
Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains
Masahiro Ono,Shun Hayashi,Kenji Matsumura,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hiroshi Mori,Hideo Saji +8 more
TL;DR: A novel series of rhodanin and thiohydantoin derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease, and the TH derivative, TH2, showed high specific binding to tau aggregates.
References
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