Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
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TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Comparative Proteomic Analysis of Intra- and Interindividual Variation in Human Cerebrospinal Fluid
TL;DR: Despite the intraindividual variations, hierarchical clustering and multidimensional scaling analysis of the proteomic profiles revealed that two CSF samples from the same individual cluster the closest together and that the between- subject variability is much larger than the within-subject variability.
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Deconstructing mitochondrial dysfunction in Alzheimer disease.
TL;DR: The novel protocols for the generation of neurons by reprogramming or direct transdifferentiation, which offer useful tools to achieve this result are summarized.
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Acetylcholine receptors in dementia and mild cognitive impairment
TL;DR: Evidence is provided for the potential of 2-[18F-A-85380 nAChR PET in the diagnosis of patients at risk for AD and the new α4β2 nA cholinergic receptors-specific radioligands (+)- and (−)-[18F]norchloro-fluoro-homoepibatidine (NCFHEB) and evaluated them preclinically.
Journal ArticleDOI
Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review.
Michele L. Ries,Cynthia M. Carlsson,Howard A. Rowley,Mark A. Sager,Carey E. Gleason,Sanjay Asthana,Sterling C. Johnson +6 more
TL;DR: In this article, the most recent developments in the use of magnetic resonance imaging (MRI) to characterize brain changes and to prognosticate clinical outcomes of patients with mild cognitive impairment (MCI) are reviewed.
Journal ArticleDOI
PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease.
J. Koivunen,Auli Verkkoniemi,S. Aalto,Anders Paetau,J.-P. Ahonen,M. Viitanen,K.B. Nagren,Johanna Rokka,M. Haaparanta,Hannu Kalimo,J. O. Rinne +10 more
TL;DR: High resolution PIB imaging shows increased uptake in patients with VarAD especially in the striatum, and it can be used to detect amyloid accumulation in vivo in these patients, and the results were essentially similar when the uptake was expressed as region-to-pons ratios.
References
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
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