Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.Abstract:
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.read more
Citations
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Journal ArticleDOI
Indicators of amyloid burden in a population-based study of cognitively normal elderly
Michelle M. Mielke,Heather J. Wiste,Stephen D. Weigand,David S. Knopman,Val J. Lowe,Rosebud O. Roberts,Yonas E. Geda,Dana Swenson-Dravis,Bradley F. Boeve,Matthew L. Senjem,Prashanthi Vemuri,Ronald C. Petersen,Clifford R. Jack +12 more
TL;DR: Age and APOE genotype are useful predictors of the likelihood of significant amyloid accumulation, but discrimination is modest, and these results suggest that inexpensive and noninvasive measures could significantly reduce the number of CN individuals needed to screen to enroll a given number of amyloids-positive subjects.
Journal ArticleDOI
Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade
TL;DR: The role of vascular factors and Aβ is reviewed, underlining that vascular risk factor management may be important for AD prevention and treatment, and if disease-modifying therapies in the pipeline show safety and efficacy.
Journal ArticleDOI
Dissecting axes of autonomic control in humans: Insights from neuroimaging
Hugo D. Critchley,Hugo D. Critchley,Yoko Nagai,Marcus A. Gray,Marcus A. Gray,Christopher J. Mathias,Christopher J. Mathias +6 more
TL;DR: Current and anticipated technical advances, including the integration of autonomically-focused microneurography and neural stimulation with advanced neuroimaging, will continue to provide detailed insight into dynamics of autonomic control.
Journal ArticleDOI
Longitudinal imaging of Alzheimer pathology using [C-11]PIB, [F-18]FDDNP and [F-18]FDG PET
Rik Ossenkoppele,Nelleke Tolboom,Jessica C. Foster-Dingley,Sofie F. Adriaanse,Ronald Boellaard,Maqsood Yaqub,Albert D. Windhorst,Frederik Barkhof,Adriaan A. Lammertsma,Philip Scheltens,Wiesje M. van der Flier,Bart N.M. van Berckel +11 more
TL;DR: Increased amyloid load in MCI patients and progressive metabolic impairment in AD patients are found and [18F]FDDNP seems to be less useful for examining disease progression.
Journal ArticleDOI
Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant.
Elizabeth C. Mormino,Michael G. Brandel,Cindee Madison,Gil D. Rabinovici,Gil D. Rabinovici,Shawn M. Marks,Suzanne L. Baker,William J. Jagust,William J. Jagust,William J. Jagust +9 more
TL;DR: A biological relevance of slight PIB elevations in aging is suggested, as a greater proportion of ambiguously elevated values compared to low values, and these elevated values were present in regions known to show amyloid deposition.
References
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